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Details on Person mTORC2 phosphorylates AKT at S473

Class:Id	Reaction:198640
_displayName	mTORC2 phosphorylates AKT at S473
_doRelease	TRUE
_timestamp	2026-01-26 17:53:59
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198624] protein serine/threonine kinase activity of mTORC2:PIP3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
input	[SimpleEntity:113592] ATP [cytosol] [Complex:2317329] AKT:PIP3 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:199373] Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex [LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
modified	[InstanceEdit:199252] Jassal, B, 2007-07-10 07:58:26 [InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36 [InstanceEdit:202099] Jassal, B, 2007-10-18 12:39:52 [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:399688] Jupe, S, 2009-03-19 10:44:20 [InstanceEdit:419653] Jupe, S, 2009-05-05 12:50:44 [InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23 [InstanceEdit:422525] Garapati, P V, 2009-06-01 19:13:02 [InstanceEdit:1262966] Jassal, B, 2011-05-06 [InstanceEdit:1273428] Jassal, B, 2011-05-11 [InstanceEdit:1306822] Jassal, B, 2011-05-27 [InstanceEdit:2316436] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317321] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317334] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2326768] Orlic-Milacic, M, 2012-06-18 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457755] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:8940386] Orlic-Milacic, Marija, 2016-09-26 [InstanceEdit:9014474] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9830718] D'Eustachio, Peter, 2023-03-13 [InstanceEdit:9980238] Orlic-Milacic, Marija, 2026-01-26 [InstanceEdit:9980239] Orlic-Milacic, Marija, 2026-01-26
name	mTORC2 phosphorylates AKT at S473
output	[SimpleEntity:29370] ADP [cytosol] [Complex:2317310] p-S-AKT:PIP3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2317332] PIP3 recruits AKT to the membrane [Homo sapiens] [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] [Reaction:389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens] [Reaction:437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] [Reaction:2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Homo sapiens] [Reaction:2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [BlackBoxEvent:9985270] EGF/FGF2 activate PI3K in neural stem cells [Homo sapiens] [Reaction:9980233] PIP3 activates mTORC2 [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [BlackBoxEvent:9985270] EGF/FGF2 activate PI3K in neural stem cells [Homo sapiens]
regulatedBy	[NegativeRegulation:199457] Negative regulation by 'AKT:PIP3:THEM4/TRIB3 [plasma membrane]'
releaseDate	2008-03-12
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361367] R-HSA-198640.6
summation	[Summation:202051] Under conditions of growth and mitogen stimulation S473 phos...
(hasEvent)	[Pathway:389357] CD28 dependent PI3K/Akt signaling [Homo sapiens] [Pathway:1257604] PIP3 activates AKT signaling [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent)	[Reaction:2317314] AKT binds PDPK1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText] [_UpdateTracker:9789479] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v38:[modifyText] [_UpdateTracker:9791333] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v31:[modifyText]
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