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Details on Person AKT phosphorylates p21Cip1 and p27Kip1

Class:IdReaction:198613
_displayNameAKT phosphorylates p21Cip1 and p27Kip1
_doReleaseTRUE
_timestamp2018-08-16 14:32:58
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
goBiologicalProcess[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:182504] CDKN1A,CDKN1B [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:199330] Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
[LiteratureReference:8949867] Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
modified[InstanceEdit:199247] Jassal, B, 2007-07-10 07:58:16
[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
[InstanceEdit:202683] Jassal, Bijay, 2007-11-08
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14
[InstanceEdit:8932657] Orlic-Milacic, Marija, 2016-07-27
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9024715] Orlic-Milacic, Marija, 2017-10-06
[InstanceEdit:9617042] Orlic-Milacic, Marija, 2018-08-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT phosphorylates p21Cip1 and p27Kip1
output[DefinedSet:198605] p-T-CDKN1A/B [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361692] R-HSA-198613.6
summation[Summation:198606] Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by...
(hasEvent)[Pathway:69202] Cyclin E associated events during G1/S transition [Homo sapiens]
[Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry [Homo sapiens]
[Pathway:198323] AKT phosphorylates targets in the cytosol [Homo sapiens]
(normalReaction)[Reaction:2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779219] Update Tracker - [Reaction:198613] AKT phosphorylates p21Cip1 and p27Kip1 - v66:[addLiteratureReference]
[_UpdateTracker:9782921] Update Tracker - [Reaction:198613] AKT phosphorylates p21Cip1 and p27Kip1 - v58:[add_removeInput]
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