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Details on Person AKT phosphorylates TSC2, inhibiting it

Class:IdReaction:198609
_displayNameAKT phosphorylates TSC2, inhibiting it
_doReleaseTRUE
_timestamp2017-10-06 16:31:19
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
edited[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014-12-23
goBiologicalProcess[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input[EntityWithAccessionedSequence:2980548] TSC2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:199381] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
[LiteratureReference:199857] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
modified[InstanceEdit:199246] Jassal, B, 2007-07-10 07:58:14
[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
[InstanceEdit:199481] Jassal, B, 2007-07-11 09:33:46
[InstanceEdit:199866] Jassal, B, 2007-07-12 14:41:47
[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
[InstanceEdit:202100] Jassal, B, 2007-10-18 12:42:20
[InstanceEdit:202667] Jassal, B, 2007-11-08 15:44:30
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:213133] Jassal, B, 2008-02-21 09:05:43
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:1366600] Orlic-Milacic, Marija, 2011-06-23
[InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14
[InstanceEdit:2399984] Orlic-Milacic, M, 2012-07-13
[InstanceEdit:2980545] Jassal, B, 2013-01-11
[InstanceEdit:2997523] Jassal, B, 2013-01-23
[InstanceEdit:5674604] Orlic-Milacic, Marija, 2015-02-13
[InstanceEdit:6797599] Orlic-Milacic, Marija, 2015-09-14
[InstanceEdit:8856007] Orlic-Milacic, Marija, 2016-02-08
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9024715] Orlic-Milacic, Marija, 2017-10-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT phosphorylates TSC2, inhibiting it
output[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:199484] p-S939,T1462-TSC2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2008-03-12
releaseStatusUPDATED
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360524] R-HSA-198609.6
summation[Summation:199479] AKT phosphorylates and inhibits TSC2 (tuberin), a suppressor...
(hasEvent)[Pathway:198323] AKT phosphorylates targets in the cytosol [Homo sapiens]
[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(normalReaction)[Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it [Homo sapiens]
(precedingEvent)[Reaction:5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783566] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v56:[modifyText]
[_UpdateTracker:9785149] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v52:[modifyText]
[_UpdateTracker:9787731] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
[_UpdateTracker:9788488] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v42:[modifyText]
[_UpdateTracker:9789180] Update Tracker - [Reaction:198609] AKT phosphorylates TSC2, inhibiting it - v38:[modifyText]
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