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Details on Person AKT phosphorylates MDM2

Class:IdReaction:198599
_displayNameAKT phosphorylates MDM2
_doReleaseTRUE
_timestamp2017-07-28 15:02:43
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48
goBiologicalProcess[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input[EntityWithAccessionedSequence:198644] MDM2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:199351] HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
[LiteratureReference:2399962] Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
[LiteratureReference:2399963] A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein
[LiteratureReference:6793667] A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
modified[InstanceEdit:199244] Jassal, B, 2007-07-10 07:58:10
[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
[InstanceEdit:202667] Jassal, B, 2007-11-08 15:44:30
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14
[InstanceEdit:2399978] Orlic-Milacic, M, 2012-07-13
[InstanceEdit:6793670] Orlic-Milacic, Marija, 2015-09-03
[InstanceEdit:6806355] Orlic-Milacic, Marija, 2015-10-22
[InstanceEdit:8856342] Orlic-Milacic, Marija, 2016-02-09
[InstanceEdit:8979256] Orlic-Milacic, Marija, 2017-02-23
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT phosphorylates MDM2
output[EntityWithAccessionedSequence:198638] p-S166,S188-MDM2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2008-03-12
releaseStatusUPDATED
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360666] R-HSA-198599.6
summation[Summation:198607] AKT phosphorylates MDM2 on two serine residues, at positions...
(hasEvent)[Pathway:198323] AKT phosphorylates targets in the cytosol [Homo sapiens]
[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(normalReaction)[Reaction:2399981] AKT1 E17K mutant phosphorylates MDM2 [Homo sapiens]
(precedingEvent)[Reaction:6793666] MDM2 translocates to the nucleus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783918] Update Tracker - [Reaction:198599] AKT phosphorylates MDM2 - v55:[addLiteratureReference, modifyText]
[_UpdateTracker:9788405] Update Tracker - [Reaction:198599] AKT phosphorylates MDM2 - v42:[addLiteratureReference, modifyText]
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