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Details on Person IDO1 dioxygenates L-Trp to NFK

Class:Id	Reaction:198563
_displayName	IDO1 dioxygenates L-Trp to NFK
_doRelease	TRUE
_timestamp	2024-11-27 18:13:02
authored	[InstanceEdit:198560] D'Eustachio, P, 2007-06-22 18:24:32
catalystActivity	[CatalystActivity:198570] L-tryptophan 2,3-dioxygenase activity of IDO1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643939] tryptophan 2,3-dioxygenase activity of IDO1 [cytosol] Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:198560] D'Eustachio, P, 2007-06-22 18:24:32
crossReference	[DatabaseIdentifier:9929636] RHEA:24537
edited	[InstanceEdit:198560] D'Eustachio, P, 2007-06-22 18:24:32
input	[SimpleEntity:29500] L-Trp [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:198567] Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
modified	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23 [InstanceEdit:1080815] D'Eustachio, P, 2010-11-27 [InstanceEdit:8939588] Jassal, Bijay, 2016-09-20 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27
name	IDO1 dioxygenates L-Trp to NFK L-tryptophan + O2 => N-formyl-L-kynurenine tryptophan + O2 => N-formylkynurenine [IDO]
output	[SimpleEntity:33179] NFK [cytosol]
precedingEvent	[Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [Homo sapiens] [Reaction:8870352] SLC36A4 transports L-Trp from extracellular region to cytosol [Homo sapiens]
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358441] R-HSA-198563.5
summation	[Summation:198565] Cytosolic indoleamine 2,3-dioxygenase (IDO) catalyzes the co...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71189] AFMID hydrolyses NFK to L-KYN [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939746] Update Tracker - [Reaction:198563] IDO1 dioxygenates L-Trp to NFK - v92:[modifyText]
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