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Details on Person MDH1 oxidizes MAL to OA

Class:IdReaction:198508
_displayNameMDH1 oxidizes MAL to OA
_doReleaseFALSE
_timestamp2025-08-25 13:30:34
authored[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
catalystActivity[CatalystActivity:198512] L-malate dehydrogenase (NAD+) activity of MDH1 dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9815320] L-malate dehydrogenase activity of MDH1 dimer [cytosol] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
compartment[Compartment:70101] cytosol
created[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
crossReference[DatabaseIdentifier:9854228] RHEA:21433
input[SimpleEntity:198498] MAL [cytosol]
[SimpleEntity:29360] NAD+ [cytosol]
literatureReference[LiteratureReference:198443] Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution
[LiteratureReference:9815321] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
[LiteratureReference:198469] Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)
[LiteratureReference:9854286] Cytosolic malate dehydrogenase regulates senescence in human fibroblasts
[LiteratureReference:9857025] MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy
[LiteratureReference:9857026] Structural Characterization of the Human Cytosolic Malate Dehydrogenase I
[LiteratureReference:9953011] Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
modified[InstanceEdit:198534] D'Eustachio, P, 2007-06-22 15:53:40
[InstanceEdit:372849] D'Eustachio, P, 2008-07-07 20:55:07
[InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9815308] D'Eustachio, Peter, 2022-08-16
[InstanceEdit:9815705] D'Eustachio, Peter, 2022-08-25
[InstanceEdit:9815858] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9854287] Stephan, Ralf, 2023-11-25
[InstanceEdit:9857024] Stephan, Ralf, 2023-12-30
[InstanceEdit:9859509] Stephan, Ralf, 2024-01-20
[InstanceEdit:9953017] Stephan, Ralf, 2025-05-28
[InstanceEdit:9956893] Stephan, Ralf, 2025-06-16
[InstanceEdit:9964568] Stephan, Ralf, 2025-08-25
nameMDH1 oxidizes MAL to OA
(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
negativePrecedingEvent[NegativePrecedingEvent:9953021] Futile Cycle: MDH1 reduces OA
output[SimpleEntity:76213] OA [cytosol]
[SimpleEntity:73473] NADH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
releaseDate2005-09-26
reviewed[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359031] R-HSA-198508.5
summation[Summation:9857019] Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the reacti...
(hasEvent)[Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791739] Update Tracker - [Reaction:198508] malate + NAD+ <=> oxaloacetate + NADH + H+ - v26:[modifyText]
[_UpdateTracker:9846874] Update Tracker - [Reaction:198508] MDH1 oxidizes MAL to OA - v83:[modifyText]
[_UpdateTracker:9846986] Update Tracker - [Reaction:198508] MDH1 oxidizes MAL to OA - v82:[addLiteratureReference, modifyText]
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