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Details on Person PI3K alpha [cytosol]

Class:Id	Complex:198379
_displayName	PI3K alpha [cytosol]
_timestamp	2010-12-02 14:48:19
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:198380] Jassal, B, 2007-06-11 10:03:37
hasComponent	[EntityWithAccessionedSequence:74787] PIK3CA [cytosol] [Homo sapiens] [CandidateSet:391342] PI3K-regulatory subunits [cytosol] [Homo sapiens]
modified	[InstanceEdit:437128] Jupe, S, 2009-09-11 [InstanceEdit:941603] Jupe, S, 2010-09-03
name	PI3K alpha
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1107503] R-HSA-198379.1
(hasCandidate)	[CandidateSet:9927349] Class 1A PI3Ks [cytosol] [Homo sapiens]
(hasComponent)	[Complex:114540] RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] [Homo sapiens] [Complex:205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Homo sapiens] [Complex:388797] pCTLA-4:PI3K [plasma membrane] [Homo sapiens] [Complex:416356] G-protein alpha (q/11):PI3K alpha [plasma membrane] [Homo sapiens] [Complex:1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] [Homo sapiens] [Complex:9021654] ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] [Homo sapiens] [Complex:9632399] Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] [Homo sapiens] [Complex:9670376] PI3K:p-KIT mutant dimers [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:437157] PI3K alpha, beta, gamma [cytosol] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] [CandidateSet:9013178] RAC1 effectors [cytosol] [Homo sapiens] [CandidateSet:9014425] RAC2 plasma membrane effectors [cytosol] [Homo sapiens]
(input)	[Reaction:114542] RAC1,RAC2,RHOG activate PI3K [Homo sapiens] [Reaction:205262] Direct recruitment of PI3K to p-KIT [Homo sapiens] [Reaction:388815] Interaction of PI3K with pCTLA-4 [Homo sapiens] [Reaction:416358] G alpha (q) inhibits PI3K alpha [Homo sapiens] [Reaction:1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 [Homo sapiens] [Reaction:9021660] PI3K binds membrane-associated estrogen receptors [Homo sapiens] [Reaction:9670431] Phosphorylated KIT mutants bind PI3K [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9869799] Update Tracker - [Complex:198379] PI3K alpha [cytosol] - v34:[add_removeHasComponent] [_UpdateTracker:9880034] Update Tracker - [Complex:198379] PI3K alpha [cytosol] - v44:[updateContainedComponent]
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No pathways have been reviewed or authored by PI3K alpha [cytosol] (198379)