Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person In line with activation of PI3-kinase (PI3K) by other recept...
| Class:Id | Summation:198351 |
|---|---|
| _displayName | In line with activation of PI3-kinase (PI3K) by other recept... |
| _timestamp | 2024-03-19 14:03:15 |
| created | [InstanceEdit:198362] Jassal, B, 2007-06-11 10:01:50 |
| modified | [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:443386] Jupe, S, 2009-10-05 [InstanceEdit:9865833] Orlic-Milacic, Marija, 2024-03-19 |
| text | In line with activation of PI3-kinase (PI3K) by other receptor tyrosine kinases, PI3K recruited to the activated NTRK1 receptor via IRS1 and/or IRS2 (Miranda et al. 2001) is thought to phosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, commonly known as PtdIn(4,5)P2 or PIP2, at the plasma membrane producing the second messenger PtdIns(3,4,5)P3, also named PIP3, as evidenced by increased PIP3 levels (Miranda et al. 2001) and increased activating phosphorylation of AKT1 (Tsuchiya et al. 2014) upon stimulation of cells with the NTRK1 ligand NGF. |
| (summation) | [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by In line with activation of PI3-kinase (PI3K) by other recept... (198351)
