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Details on Person Active IRS recruits PI3K to the plasma membrane and activates it

Class:Id	Reaction:198315
_displayName	Active IRS recruits PI3K to the plasma membrane and activates it
_doRelease	TRUE
_timestamp	2017-04-06 15:46:11
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:198310] 2007-07-10 08:01:55
input	[Complex:198299] Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] [Homo sapiens] [Complex:74693] PI3K [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:198308] IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1
modified	[InstanceEdit:198362] Jassal, B, 2007-06-11 10:01:50 [InstanceEdit:198616] Jassal, B, 2007-06-29 07:57:48 [InstanceEdit:202683] Jassal, Bijay, 2007-11-08 [InstanceEdit:210884] Jassal, B, 2008-01-17 14:46:44 [InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56 [InstanceEdit:213134] Jassal, B, 2008-02-21 09:11:01 [InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23 [InstanceEdit:264545] Jassal, B, 2008-04-03 09:03:06 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active IRS recruits PI3K to the plasma membrane and activates it
output	[Complex:213135] Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:198295] TRKA phosphorylates IRS [Homo sapiens] [Reaction:198211] Active TRKA binds IRS1/2 [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359404] R-HSA-198315.4
summation	[Summation:198350] The PI3K regulatory subunit p85 binds to IRS1 or IRS2, tyros...
(hasEvent)	[Pathway:198203] PI3K/AKT activation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781394] Update Tracker - [Reaction:198315] Active IRS recruits PI3K to the plasma membrane and activates it - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9791805] Update Tracker - [Reaction:198315] Active IRS recruits PI3K to the plasma membrane and activates it - v25:[add_removeInput]
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