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Details on Person DAG stimulates protein kinase C-delta

Class:Id	Reaction:198314
_displayName	DAG stimulates protein kinase C-delta
_doRelease	TRUE
_timestamp	2025-09-19 09:39:36
catalystActivity	[CatalystActivity:198312] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PKC-delta/epsilon [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:198310] 2007-07-10 08:01:55
input	[DefinedSet:198276] PKC-delta/epsilon [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:8984416] Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions [LiteratureReference:8984434] PKD at the crossroads of DAG and PKC signaling
modified	[InstanceEdit:204298] Jassal, Bijay, 2007-11-28 [InstanceEdit:549123] Jassal, B, 2010-03-17 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:2024058] Williams, MG, 2011-12-13 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966345] Stephan, Ralf, 2025-09-19
name	DAG stimulates protein kinase C-delta
output	[DefinedSet:198265] Phospho-PKC-delta/epsilon [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens] [Reaction:167684] Active PLCG1 dissociates from TrkA receptor [Homo sapiens] [Reaction:212713] Active PLC-gamma1 dissociates from EGFR [Homo sapiens] [Reaction:2029272] Release of PLCG from FCGR [Homo sapiens] [Reaction:2029271] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:4420202] PLCG1 disassociates from VEGFR2 and translocate to PM [Homo sapiens] [Reaction:5654157] p-4Y-PLCG1 dissociates from activated FGFR2 [Homo sapiens] [Reaction:5654148] p-4Y-PLCG1 dissociates from activated FGFR3 [Homo sapiens] [Reaction:5654169] p-4Y-PLCG1 dissociates from activated FGFR4 [Homo sapiens] [Reaction:5654165] p-4Y-PLCG1 dissociates from activated FGFR1 [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens]
regulatedBy	[PositiveRegulation:1489502] Positive regulation by 'DAG [plasma membrane]'
releaseDate	2011-09-20
requiredInputComponent	[SimpleEntity:114519] DAG [plasma membrane]
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361986] R-HSA-198314.5
summation	[Summation:198288] Diacylglycerol (DAG) positively regulates the autophosphoryl...
(hasEvent)	[Pathway:1489509] DAG and IP3 signaling [Homo sapiens] [Pathway:2029485] Role of phospholipids in phagocytosis [Homo sapiens]
(precedingEvent)	[Reaction:2029471] Hydrolysis of PC to PA by PLD [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780947] Update Tracker - [Reaction:198314] DAG stimulates protein kinase C-delta - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9789369] Update Tracker - [Reaction:198314] DAG stimulates protein kinase C-delta - v38:[addRegulator] [_UpdateTracker:9790487] Update Tracker - [Reaction:198314] DAG stimulates protein kinase C-delta - v33:[modifyText] [_UpdateTracker:9971907] Update Tracker - [Reaction:198314] DAG stimulates protein kinase C-delta - v95:[add_removeRegulator]
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