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Details on Person PDPK1 phosphorylates AKT at T308

Class:IdReaction:198270
_displayNamePDPK1 phosphorylates AKT at T308
_doReleaseTRUE
_timestamp2023-03-17 21:39:17
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity[CatalystActivity:198343] protein serine/threonine kinase activity of p-S-AKT:PDPK1:PIP3 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:198310] 2007-07-10 08:01:55
edited[InstanceEdit:2426555] Matthews, L, 2012-08-03
input[SimpleEntity:113592] ATP [cytosol]
[Complex:2317313] p-S-AKT:PDPK1:PIP3 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:199386] Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
[LiteratureReference:199355] Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
modified[InstanceEdit:198362] Jassal, B, 2007-06-11 10:01:50
[InstanceEdit:198702] 2007-07-10 08:01:56
[InstanceEdit:199254] Jassal, B, 2007-07-10 07:58:32
[InstanceEdit:199260] Jassal, B, 2007-07-10 07:58:44
[InstanceEdit:199370] Jassal, B, 2007-07-10 08:08:36
[InstanceEdit:202683] Jassal, Bijay, 2007-11-08
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:422361] D'Eustachio, P, 2009-05-28 17:55:23
[InstanceEdit:422524] Garapati, P V, 2009-06-01 19:11:32
[InstanceEdit:1262966] Jassal, B, 2011-05-06
[InstanceEdit:1273428] Jassal, B, 2011-05-11
[InstanceEdit:1306822] Jassal, B, 2011-05-27
[InstanceEdit:2317320] Orlic-Milacic, M, 2012-06-09
[InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08
[InstanceEdit:2457741] Orlic-Milacic, M, 2012-08-28
[InstanceEdit:2460084] Orlic-Milacic, M, 2012-08-30
[InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30
[InstanceEdit:2463869] Orlic-Milacic, M, 2012-08-31
[InstanceEdit:5357492] Garapati, P V, 2014-03-21
[InstanceEdit:9014474] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9014477] Orlic-Milacic, Marija, 2017-07-28
[InstanceEdit:9735876] Shamovsky, Veronica, 2021-07-05
[InstanceEdit:9751156] Shamovsky, Veronica, 2021-08-18
[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
[InstanceEdit:9766206] Shamovsky, Veronica, 2022-02-18
[InstanceEdit:9768017] Shamovsky, Veronica, 2022-03-03
[InstanceEdit:9796142] Shamovsky, Veronica, 2022-08-05
[InstanceEdit:9796513] Shamovsky, Veronica, 2022-08-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9831004] D'Eustachio, Peter, 2023-03-17
namePDPK1 phosphorylates AKT at T308
output[SimpleEntity:29370] ADP [cytosol]
[Complex:377179] PDPK1:PIP3 [plasma membrane] [Homo sapiens]
[CandidateSet:202074] p-T,p-S-AKT [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9766197] Negative regulation by 'N:M:PDPK1 [plasma membrane]'
regulationReference[RegulationReference:9766208] Negative regulation by 'N:M:PDPK1 [plasma membrane]' SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells
releaseDate2008-03-12
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361754] R-HSA-198270.6
summation[Summation:198363] Once AKT is localized at the plasma membrane, it is phosphor...
(hasEvent)[Pathway:389357] CD28 dependent PI3K/Akt signaling [Homo sapiens]
[Pathway:1257604] PIP3 activates AKT signaling [Homo sapiens]
[Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
[Pathway:9755779] SARS-CoV-2 targets host intracellular signalling and regulatory pathways [Homo sapiens]
[Pathway:9980201] HES3 Signaling Axis [Homo sapiens]
(precedingEvent)[Reaction:165162] Phosphorylation of TSC2 by AKT (PKB) [Homo sapiens]
[Reaction:165182] Phosphorylation of complexed TSC2 by PKB [Homo sapiens]
[Reaction:198298] AKT translocates to the nucleus [Homo sapiens]
[Reaction:198347] AKT phosphorylates BAD [Homo sapiens]
[Reaction:198371] AKT phosphorylates GSK3 [Homo sapiens]
[Reaction:198599] AKT phosphorylates MDM2 [Homo sapiens]
[Reaction:198609] AKT phosphorylates TSC2, inhibiting it [Homo sapiens]
[Reaction:198611] AKT phosphorylates IKKalpha [Homo sapiens]
[Reaction:198613] AKT phosphorylates p21Cip1 and p27Kip1 [Homo sapiens]
[Reaction:198621] AKT phosphorylates caspase-9 [Homo sapiens]
List all 23 refering instances
(updatedInstance)[_UpdateTracker:9775001] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v80:[addRegulator]
[_UpdateTracker:9788458] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v42:[add_removeInput, add_removeOutput, modifyText, removeRegulator]
[_UpdateTracker:9791324] Update Tracker - [Reaction:198270] PDPK1 phosphorylates AKT at T308 - v31:[modifyText]
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