Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Active TRKA binds IRS1/2

Class:IdReaction:198211
_displayNameActive TRKA binds IRS1/2
_doReleaseTRUE
_timestamp2024-03-18 20:06:13
authored[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment[Compartment:947587] cytoplasmic side of plasma membrane
created[InstanceEdit:198207] Jassal, Bijay, 2007-05-21
inferredFrom
input[DefinedSet:198273] IRS1,2 [cytosol] [Homo sapiens]
[Complex:166540] Activated TrkA receptor complex [plasma membrane] [Homo sapiens]
modified[InstanceEdit:198310] 2007-07-10 08:01:55
[InstanceEdit:199916] Jassal, B, 2007-07-13 13:44:04
[InstanceEdit:202683] Jassal, Bijay, 2007-11-08
[InstanceEdit:211298] Jassal, B, 2008-01-30 10:40:56
[InstanceEdit:215417] Jassal, B, 2008-02-28 15:14:23
[InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
nameActive TRKA binds IRS1/2
negativePrecedingEvent[NegativePrecedingEvent:9865763] Futile Cycle: Active PLCG1 dissociates from TrkA receptor
[NegativePrecedingEvent:9865765] Futile Cycle: Phospho-Shc dissociates from the TrkA receptor
output[Complex:198307] Activated TrkA receptor:IRS1/2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359005] R-HSA-198211.4
summation[Summation:198210] IRS1 and IRS2 bind directly to TRK receptors phosphorylated ...
(hasEvent)[Pathway:198203] PI3K/AKT activation [Homo sapiens]
(precedingEvent)[Reaction:198295] TRKA phosphorylates IRS [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Active TRKA binds IRS1/2 (198211)