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Details on Person Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

Class:Id	Reaction:1981104
_displayName	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
_doRelease	TRUE
_timestamp	2021-07-15 15:37:08
authored	[InstanceEdit:913966] Jupe, S, 2010-07-20
catalystActivity	[CatalystActivity:1981145] procollagen-lysine 5-dioxygenase activity of Lysyl hydroxylases [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1981143] Jupe, S, 2011-11-09
edited	[InstanceEdit:2247551] Jupe, S, 2012-05-14
input	[Complex:2023011] Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:1650779] 2OG [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2265540] Human lysyl hydroxylase: purification to homogeneity, partial characterization and comparison of catalytic properties with those of a mutant enzyme from Ehlers-Danlos syndrome type VI fibroblasts [LiteratureReference:1981131] Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2 [LiteratureReference:1981116] Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle [LiteratureReference:1981133] Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3)
modified	[InstanceEdit:2022143] Jupe, S, 2011-11-25 [InstanceEdit:2022496] Jupe, S, 2011-11-29 [InstanceEdit:2023013] Jupe, S, 2011-12-01 [InstanceEdit:2193145] Jupe, S, 2012-04-12 [InstanceEdit:2247895] Jupe, S, 2012-05-14 [InstanceEdit:2265538] Jupe, S, 2012-05-21 [InstanceEdit:2267323] Jupe, S, 2012-05-24 [InstanceEdit:2268948] Jupe, S, 2012-05-25 [InstanceEdit:2395383] Jupe, S, 2012-06-29 [InstanceEdit:8948235] Jupe, Steve, 2016-11-11 [InstanceEdit:8948390] Jupe, Steve, 2016-11-14 [InstanceEdit:9736955] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
output	[Complex:2022428] Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:1650769] SUCCA [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:9733216] COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 [Homo sapiens] [Reaction:9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter [Homo sapiens] [Reaction:9733247] YBX1 binds COL1A2 gene promoter [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2267224] Canty-Laird, EG, 2012-05-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294784] R-HSA-1981104.4
summation	[Summation:1981158] Lysyl hydroxylase (LH) (E.C. 1.14.11.4) is a dimeric enzyme ...
(hasEvent)	[Pathway:1650814] Collagen biosynthesis and modifying enzymes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788354] Update Tracker - [Reaction:1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - v42:[modifyText, removeInput, removeOutput]
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No pathways have been reviewed or authored by Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (1981104)