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Details on Person NOTCH1:DLL/JAG complex is cleaved to produce NEXT1

Class:IdReaction:1980134
_displayNameNOTCH1:DLL/JAG complex is cleaved to produce NEXT1
_doReleaseFALSE
_timestamp2016-07-15 23:49:43
catalystActivity[CatalystActivity:1852619] metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:1980135] Orlic-Milacic, M, 2011-11-08
input[Complex:1911537] Ub-DLL/JAG:NOTCH1 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:157022] The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
[LiteratureReference:157210] A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
modified[InstanceEdit:1980136] Orlic-Milacic, M, 2011-11-08
[InstanceEdit:1983666] Orlic-Milacic, M, 2011-11-10
[InstanceEdit:5694711] Orlic-Milacic, Marija, 2015-05-22
[InstanceEdit:8879177] Wu, G, 2016-07-15
nameNOTCH1:DLL/JAG complex is cleaved to produce NEXT1
output[EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] [Homo sapiens]
[Complex:1911540] Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8902436] R-HSA-1980134.1
summation[Summation:178983] Ligand binding induces a conformational change in NOTCH1, pr...
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