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Details on Person JAG1 binds NOTCH2

Class:Id	Reaction:1980056
_displayName	JAG1 binds NOTCH2
_doRelease	TRUE
_timestamp	2024-10-24 17:44:22
authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1980057] Orlic-Milacic, M, 2011-11-08
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
entityOnOtherCell	[EntityWithAccessionedSequence:157098] JAG1 [plasma membrane] [Homo sapiens]
inferredFrom	[Reaction:2032378] Jag1 binds Notch2 [Mus musculus] [Reaction:1980061] JAG2 binds NOTCH2 [Homo sapiens] [Reaction:2032379] Jag2 binds Notch2 [Mus musculus]
input	[EntityWithAccessionedSequence:157098] JAG1 [plasma membrane] [Homo sapiens] [DefinedSet:2168114] NOTCH2/Fringe-modified NOTCH2 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9919303] Matthews, Lisa, 2024-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 [LiteratureReference:2169058] Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods [LiteratureReference:2168111] Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 [LiteratureReference:3322874] Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur [LiteratureReference:3325524] Glomerular mesangiolipidosis in Alagille syndrome (arteriohepatic dysplasia) [LiteratureReference:3322873] Mutations in the human Jagged1 gene are responsible for Alagille syndrome [LiteratureReference:3322887] Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 [LiteratureReference:2025784] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway [LiteratureReference:3325525] Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation [LiteratureReference:3325529] A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency [LiteratureReference:9911406] Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis [LiteratureReference:9911412] Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
modified	[InstanceEdit:2060799] Orlic-Milacic, M, 2012-01-16 [InstanceEdit:2169061] Orlic-Milacic, M, 2012-03-27 [InstanceEdit:2169064] Orlic-Milacic, M, 2012-03-27 [InstanceEdit:2980008] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:3159305] Orlic-Milacic, M, 2013-02-20 [InstanceEdit:3168185] Orlic-Milacic, M, 2013-02-23 [InstanceEdit:3168188] Orlic-Milacic, M, 2013-02-24 [InstanceEdit:3325537] Orlic-Milacic, M, 2013-05-09 [InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03 [InstanceEdit:9911718] Orlic-Milacic, Marija, 2024-06-04 [InstanceEdit:9919304] Orlic-Milacic, Marija, 2024-08-20 [InstanceEdit:9925743] Orlic-Milacic, Marija, 2024-10-22 [InstanceEdit:9925767] Orlic-Milacic, Marija, 2024-10-24
name	JAG1 binds NOTCH2
output	[Complex:1980058] JAG1:NOTCH2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1912382] Mature NOTCH heterodimer traffics to the plasma membrane [Homo sapiens] [Reaction:1912369] NOTCH precursor cleaved to form mature NOTCH [Homo sapiens] [BlackBoxEvent:1912379] Transport of fringe-modified NOTCH to plasma membrane [Homo sapiens] [Reaction:1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:9911657] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]'
regulationReference	[RegulationReference:9911716] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]' Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
releaseDate	2013-03-12
reviewed	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25 [InstanceEdit:9925739] Heide, Michael, 2024-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200409] R-HSA-1980056.4
structureModified	[InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03
summation	[Summation:2169062] JAG1, expressed on a neighboring cell, binds NOTCH2 and a...
(hasEvent)	[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)	[Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 [Homo sapiens]
(replacementInstances)	[_Deleted:5694726] Deletion of instance: 157083 [_Deleted:5694728] Deletion of instance: 157651
(updatedInstance)	[_UpdateTracker:9787363] Update Tracker - [Reaction:1980056] JAG1 binds NOTCH2 - v45:[addLiteratureReference, modifyText] [_UpdateTracker:9919522] Update Tracker - [Reaction:1980056] JAG1 binds NOTCH2 - v90:[modifyText, removeLiteratureReference, removeRegulator]
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