Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person DLL4 binds NOTCH2

Class:Id	Reaction:1980051
_displayName	DLL4 binds NOTCH2
_doRelease	TRUE
_timestamp	2024-10-24 17:44:16
authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1980052] Orlic-Milacic, M, 2011-11-08
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
entityOnOtherCell	[EntityWithAccessionedSequence:158437] DLL4 [plasma membrane] [Homo sapiens]
input	[EntityWithAccessionedSequence:158437] DLL4 [plasma membrane] [Homo sapiens] [Complex:157005] NOTCH2 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9919303] Matthews, Lisa, 2024-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:2168113] Function of Delta4 gene and its effects on 32D cell differentiation [LiteratureReference:9911406] Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis [LiteratureReference:9911412] Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
modified	[InstanceEdit:2168118] Orlic-Milacic, M, 2012-03-23 [InstanceEdit:2169061] Orlic-Milacic, M, 2012-03-27 [InstanceEdit:2172131] Orlic-Milacic, M, 2012-03-28 [InstanceEdit:2980008] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:3159305] Orlic-Milacic, M, 2013-02-20 [InstanceEdit:3168185] Orlic-Milacic, M, 2013-02-23 [InstanceEdit:3168188] Orlic-Milacic, M, 2013-02-24 [InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03 [InstanceEdit:9911718] Orlic-Milacic, Marija, 2024-06-04 [InstanceEdit:9919304] Orlic-Milacic, Marija, 2024-08-20 [InstanceEdit:9925743] Orlic-Milacic, Marija, 2024-10-22 [InstanceEdit:9925767] Orlic-Milacic, Marija, 2024-10-24
name	DLL4 binds NOTCH2
output	[Complex:1980053] DLL4:NOTCH2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1912382] Mature NOTCH heterodimer traffics to the plasma membrane [Homo sapiens] [Reaction:1912369] NOTCH precursor cleaved to form mature NOTCH [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:9911657] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]'
regulationReference	[RegulationReference:9911716] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]' Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
releaseDate	2013-03-12
reviewed	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25 [InstanceEdit:9925739] Heide, Michael, 2024-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200723] R-HSA-1980051.4
structureModified	[InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03
summation	[Summation:2169060] DLL4, expressed on a neighboring cell, binds NOTCH2 recep...
(hasEvent)	[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)	[Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 [Homo sapiens]
(replacementInstances)	[_Deleted:5694726] Deletion of instance: 157083 [_Deleted:5694728] Deletion of instance: 157651
(updatedInstance)	[_UpdateTracker:9919372] Update Tracker - [Reaction:1980051] DLL4 binds NOTCH2 - v90:[modifyText, removeLiteratureReference, removeRegulator]
[Change default viewing format]

No pathways have been reviewed or authored by DLL4 binds NOTCH2 (1980051)