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Details on Person DLL1 binds NOTCH2

Class:Id	Reaction:1980048
_displayName	DLL1 binds NOTCH2
_doRelease	TRUE
_timestamp	2024-10-24 17:44:14
authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1980049] Orlic-Milacic, M, 2011-11-08
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:9925757] Orlic-Milacic, Marija, 2024-10-23
entityOnOtherCell	[EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] [Homo sapiens]
inferredFrom	[Reaction:2060798] Dll1 binds Notch2 [Mus musculus]
input	[EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] [Homo sapiens] [DefinedSet:2168114] NOTCH2/Fringe-modified NOTCH2 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9919303] Matthews, Lisa, 2024-06-17
isChimeric	FALSE
literatureReference	[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 [LiteratureReference:2168111] Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 [LiteratureReference:2168112] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury [LiteratureReference:2179383] A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF [LiteratureReference:9911406] Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis [LiteratureReference:9911412] Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
modified	[InstanceEdit:2060797] Orlic-Milacic, M, 2012-01-16 [InstanceEdit:2168116] Orlic-Milacic, M, 2012-03-23 [InstanceEdit:2169056] Orlic-Milacic, M, 2012-03-27 [InstanceEdit:2979099] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:2980008] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:3159305] Orlic-Milacic, M, 2013-02-20 [InstanceEdit:3168185] Orlic-Milacic, M, 2013-02-23 [InstanceEdit:3168188] Orlic-Milacic, M, 2013-02-24 [InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03 [InstanceEdit:9911718] Orlic-Milacic, Marija, 2024-06-04 [InstanceEdit:9919304] Orlic-Milacic, Marija, 2024-08-20 [InstanceEdit:9925743] Orlic-Milacic, Marija, 2024-10-22 [InstanceEdit:9925767] Orlic-Milacic, Marija, 2024-10-24
name	DLL1 binds NOTCH2
output	[Complex:1980050] DLL1:NOTCH2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1912382] Mature NOTCH heterodimer traffics to the plasma membrane [Homo sapiens] [Reaction:1912369] NOTCH precursor cleaved to form mature NOTCH [Homo sapiens] [BlackBoxEvent:1912379] Transport of fringe-modified NOTCH to plasma membrane [Homo sapiens] [Reaction:1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:9911657] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]'
regulationReference	[RegulationReference:9911716] Positive regulation by 'NOTCH2NLB,(NOTCH2NLA,NOTCH2NLC) [extracellular region]' Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
releaseDate	2013-03-12
reviewed	[InstanceEdit:3159303] Haw, R, 2013-01-14 [InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25 [InstanceEdit:9925739] Heide, Michael, 2024-10-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200719] R-HSA-1980048.4
structureModified	[InstanceEdit:9911666] Orlic-Milacic, Marija, 2024-06-03
summation	[Summation:2169055] DLL1, expressed on the surface of a neighboring cell, bin...
(hasEvent)	[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)	[Reaction:2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 [Homo sapiens]
(replacementInstances)	[_Deleted:5694726] Deletion of instance: 157083 [_Deleted:5694728] Deletion of instance: 157651
(updatedInstance)	[_UpdateTracker:9919505] Update Tracker - [Reaction:1980048] DLL1 binds NOTCH2 - v90:[modifyText, removeLiteratureReference, removeRegulator]
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No pathways have been reviewed or authored by DLL1 binds NOTCH2 (1980048)