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Details on Person NOTCH1 binds JAG2

Class:IdReaction:1980044
_displayNameNOTCH1 binds JAG2
_doReleaseTRUE
_timestamp2016-11-10 00:55:54
authored[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1980045] Orlic-Milacic, M, 2011-11-08
edited[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell[EntityWithAccessionedSequence:157120] JAG2 [plasma membrane] [Homo sapiens]
input[Complex:157027] NOTCH1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:157120] JAG2 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:157224] Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
[LiteratureReference:2053968] Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
modified[InstanceEdit:2053972] Orlic-Milacic, M, 2012-01-12
[InstanceEdit:2122946] Orlic-Milacic, M, 2012-02-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH1 binds JAG2
output[Complex:157140] JAG2:NOTCH1 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-03-13
reviewed[InstanceEdit:165114] Joutel, A, 2004-12-15
[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2158176] R-HSA-1980044.3
summation[Summation:2053971] NOTCH1 is activated by JAG2 ligand expressed on a neighborin...
(hasEvent)[Pathway:2122948] Activated NOTCH1 Transmits Signal to the Nucleus [Homo sapiens]
(normalReaction)[FailedReaction:2660816] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 [Homo sapiens]
[Reaction:2691214] NOTCH1 HD domain mutants bind JAG2 [Homo sapiens]
[Reaction:2768993] NOTCH1 PEST domain mutants bind JAG2 [Homo sapiens]
[Reaction:2900756] NOTCH1 HD+PEST domain mutants bind JAG2 [Homo sapiens]
(precedingEvent)[Reaction:1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 [Homo sapiens]
(replacementInstances)[_Deleted:2060818] Deletion of instance: 157045
[_Deleted:5694726] Deletion of instance: 157083
[_Deleted:5694729] Deletion of instance: 157645
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No pathways have been reviewed or authored by NOTCH1 binds JAG2 (1980044)