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Details on Person PTPN6 [cytosol]
Class:Id EntityWithAccessionedSequence:197938
_displayName PTPN6 [cytosol]
_timestamp 2013-05-28 19:19:27
compartment [Compartment:70101] cytosol
created [InstanceEdit:197937] de Bono, B, 2007-05-15 16:54:47
endCoordinate 595
modified [InstanceEdit:914066] Jupe, S, 2010-07-21 [InstanceEdit:1169190] Jupe, S, 2011-01-13 [InstanceEdit:3632907] Wu, G, 2013-05-28
name PTPN6 SHP1 SHP-1 Src homology phosphatase-1 Protein-tyrosine phosphatase, non-receptor type 6 PTN6_HUMAN
referenceEntity [ReferenceGeneProduct:62433] UniProt:P29350 PTPN6 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:369517] R-HSA-197938.1
startCoordinate 1
(activeUnit) [CatalystActivity:1169238] protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane]
(hasComponent) [Complex:205181] PTPN6:p-c-Kit complex [plasma membrane] [Homo sapiens] [Complex:210221] PECAM-1:SHP-1 complex [plasma membrane] [Homo sapiens] [Complex:210224] CEACAM1:SHP-1 complex [plasma membrane] [Homo sapiens] [Complex:210237] pTREML1:SHP-1 complex [plasma membrane] [Homo sapiens] [Complex:398209] PI4P:PIP5K1gamma:SHP-1:Talin-1 [plasma membrane] [Homo sapiens] [Complex:398252] PI4P:Phospho PIP5K1gamma:SHP-1:Talin-1 [plasma membrane] [Homo sapiens] [Complex:877296] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SHP-1 [plasma membrane] [Homo sapiens] [Complex:913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] [Homo sapiens] [Complex:1169239] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1 [plasma membrane] [Homo sapiens] [Complex:1169243] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] [Homo sapiens]
(hasMember) [DefinedSet:389744] PTPN6,PTPN11 [cytosol] [Homo sapiens] [DefinedSet:997298] PTPs-SHP1/2/PTP1B [cytosol] [Homo sapiens]
(input) [Reaction:205306] Interaction of SHP1 and KIT [Homo sapiens] [Reaction:210277] Interaction of PECAM-1 and SHP-1 [Homo sapiens] [Reaction:210279] Interaction of CEACAM1 and SHP-1 [Homo sapiens] [Reaction:210281] Interaction of TREML1 and SHP-1 [Homo sapiens] [Reaction:392337] Shp-1 binds to phosphorylated PIP5K1gamma [Homo sapiens] [Reaction:1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex [Homo sapiens] [Reaction:5690701] SHP1 binds p-CD22 [Homo sapiens]
(output) [BlackBoxEvent:9851072] DNMT1-dependent PTPN6 gene silencing [Homo sapiens]
(physicalEntity) [CatalystActivity:210267] protein tyrosine phosphatase activity of PTPN6 [cytosol] [CatalystActivity:392414] protein tyrosine phosphatase activity of PTPN6 [cytosol]
(regulator) [NegativeRegulation:877279] Negative regulation by 'PTPN6 [cytosol]'
(updatedInstance) [_UpdateTracker:9869577] Update Tracker - [EntityWithAccessionedSequence:197938] PTPN6 [cytosol] - v34:[addName] [_UpdateTracker:9869931] Update Tracker - [EntityWithAccessionedSequence:197938] PTPN6 [cytosol] - v36:[addName]
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Pathways
No pathways have been reviewed or authored by PTPN6 [cytosol] (197938)