Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PTPN6 [cytosol]

Class:IdEntityWithAccessionedSequence:197938
_displayNamePTPN6 [cytosol]
_timestamp2013-05-28 19:19:27
compartment[Compartment:70101] cytosol
created[InstanceEdit:197937] de Bono, B, 2007-05-15 16:54:47
endCoordinate595
modified[InstanceEdit:914066] Jupe, S, 2010-07-21
[InstanceEdit:1169190] Jupe, S, 2011-01-13
[InstanceEdit:3632907] Wu, G, 2013-05-28
namePTPN6
SHP1
SHP-1
Src homology phosphatase-1
Protein-tyrosine phosphatase, non-receptor type 6
PTN6_HUMAN
referenceEntity[ReferenceGeneProduct:62433] UniProt:P29350 PTPN6 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369517] R-HSA-197938.1
startCoordinate1
(activeUnit)[CatalystActivity:1169238] protein tyrosine phosphatase activity of Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane]
(hasComponent)[Complex:205181] PTPN6:p-c-Kit complex [plasma membrane] [Homo sapiens]
[Complex:210221] PECAM-1:SHP-1 complex [plasma membrane] [Homo sapiens]
[Complex:210224] CEACAM1:SHP-1 complex [plasma membrane] [Homo sapiens]
[Complex:210237] pTREML1:SHP-1 complex [plasma membrane] [Homo sapiens]
[Complex:398209] PI4P:PIP5K1gamma:SHP-1:Talin-1 [plasma membrane] [Homo sapiens]
[Complex:398252] PI4P:Phospho PIP5K1gamma:SHP-1:Talin-1 [plasma membrane] [Homo sapiens]
[Complex:877296] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SHP-1 [plasma membrane] [Homo sapiens]
[Complex:913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] [Homo sapiens]
[Complex:1169239] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1 [plasma membrane] [Homo sapiens]
[Complex:1169243] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] [Homo sapiens]
List all 11 refering instances
(hasMember)[DefinedSet:389744] PTPN6,PTPN11 [cytosol] [Homo sapiens]
[DefinedSet:997298] PTPs-SHP1/2/PTP1B [cytosol] [Homo sapiens]
(input)[Reaction:205306] Interaction of SHP1 and KIT [Homo sapiens]
[Reaction:210277] Interaction of PECAM-1 and SHP-1 [Homo sapiens]
[Reaction:210279] Interaction of CEACAM1 and SHP-1 [Homo sapiens]
[Reaction:210281] Interaction of TREML1 and SHP-1 [Homo sapiens]
[Reaction:392337] Shp-1 binds to phosphorylated PIP5K1gamma [Homo sapiens]
[Reaction:1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex [Homo sapiens]
[Reaction:5690701] SHP1 binds p-CD22 [Homo sapiens]
(output)[BlackBoxEvent:9851072] DNMT1-dependent PTPN6 gene silencing [Homo sapiens]
(physicalEntity)[CatalystActivity:210267] protein tyrosine phosphatase activity of PTPN6 [cytosol]
[CatalystActivity:392414] protein tyrosine phosphatase activity of PTPN6 [cytosol]
(regulator)[NegativeRegulation:877279] Negative regulation by 'PTPN6 [cytosol]'
(updatedInstance)[_UpdateTracker:9869577] Update Tracker - [EntityWithAccessionedSequence:197938] PTPN6 [cytosol] - v34:[addName]
[_UpdateTracker:9869931] Update Tracker - [EntityWithAccessionedSequence:197938] PTPN6 [cytosol] - v36:[addName]
[Change default viewing format]
No pathways have been reviewed or authored by PTPN6 [cytosol] (197938)