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Details on Person UniProt:Q58EX2-3 SDK2
| Class:Id | ReferenceIsoform:197843 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 6 2015;chain:21-2172 added on Fri February 6 2015 |
| _displayName | UniProt:Q58EX2-3 SDK2 |
| _timestamp | 2024-11-03 19:48:33 |
| chain | signal peptide:1-20 chain:21-2172 |
| checksum | 3CAF9FE659C72A03 |
| comment | FUNCTION Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.SUBUNIT Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.INTERACTION The PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.SIMILARITY Belongs to the sidekick family.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Discerning change - Issue 176 of February 2016 |
| created | [InstanceEdit:197856] de Bono, B, 2007-05-15 13:53:41 |
| description | recommendedName: fullName evidence="1"Protein sidekick-2 |
| geneName | SDK2 KIAA1514 |
| identifier | Q58EX2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SDK2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990969] ENSEMBL:ENSG00000069188 SDK2 [Homo sapiens] |
| secondaryIdentifier | SDK2_HUMAN A6NMR8 C9JA57 Q86VY3 Q9NTD2 Q9NVB3 Q9P214 |
| sequenceLength | 2172 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q58EX2-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q58EX2-3 SDK2 (197843)
