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Details on Person UniProt:Q9NQ25-2 SLAMF7
| Class:Id | ReferenceIsoform:197841 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;chain:23-335 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NQ25-2 SLAMF7 |
| _timestamp | 2025-05-21 21:15:08 |
| chain | signal peptide:1-22 chain:23-335 |
| checksum | D09ABBCFF74BE8D4 |
| comment | FUNCTION Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).FUNCTION Isoform 3 does not mediate any NK cell activation.SUBUNIT Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536). Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).INTERACTION Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.DOMAIN The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).MISCELLANEOUS Proposed to be involved in systemic lupus erythematosus (SLE) disease process. |
| created | [InstanceEdit:197856] de Bono, B, 2007-05-15 13:53:41 |
| description | recommendedName: SLAM family member 7 alternativeName: CD2 subset 1 alternativeName: CD2-like receptor-activating cytotoxic cells shortName: CRACC alternativeName: Membrane protein FOAP-12 alternativeName: Novel Ly9 alternativeName: Protein 19A cdAntigenNameCD319/cdAntigenName |
| geneName | SLAMF7 CS1 UNQ576/PRO1138 |
| identifier | Q9NQ25 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Immunity Immunoglobulin domain Innate immunity Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SLAMF7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004395] ENSEMBL:ENSG00000026751 SLAMF7 [Homo sapiens] |
| secondaryIdentifier | SLAF7_HUMAN A8K3U1 B4DPU4 B4DPY3 B4DWA3 Q8N6Y8 Q8ND32 Q9NY08 Q9NY23 |
| sequenceLength | 335 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NQ25-2 |
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No pathways have been reviewed or authored by UniProt:Q9NQ25-2 SLAMF7 (197841)
