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Details on Person UniProt:O95297-1 MPZL1
| Class:Id | ReferenceIsoform:197839 |
|---|---|
| _chainChangeLog | signal peptide:1-35 added on Fri February 6 2015;chain:36-269 added on Fri February 6 2015 |
| _displayName | UniProt:O95297-1 MPZL1 |
| _timestamp | 2024-11-03 20:06:19 |
| chain | signal peptide:1-35 chain:36-269 |
| checksum | A1B299041EE59425 |
| comment | FUNCTION Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.SUBUNIT Interacts with phosphorylated PTPN11/SHP-2.INTERACTION Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.DOMAIN Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.PTM Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).PTM N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).SIMILARITY Belongs to the myelin P0 protein family. |
| created | [InstanceEdit:197856] de Bono, B, 2007-05-15 13:53:41 |
| description | recommendedName: Myelin protein zero-like protein 1 alternativeName: Protein zero-related |
| geneName | MPZL1 PZR UNQ849/PRO1787 |
| identifier | O95297 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MPZL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991402] ENSEMBL:ENSG00000197965 MPZL1 [Homo sapiens] |
| secondaryIdentifier | MPZL1_HUMAN B2REB9 B2REC0 Q5R332 Q8IX11 Q9BWZ3 Q9NYK4 Q9UL20 |
| sequenceLength | 269 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O95297-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95297-1 MPZL1 (197839)
