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Details on Person UniProt:Q969P0-1 IGSF8
| Class:Id | ReferenceIsoform:197798 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-613 added on Fri February 6 2015 |
| _displayName | UniProt:Q969P0-1 IGSF8 |
| _timestamp | 2024-11-03 19:41:23 |
| chain | signal peptide:1-27 chain:28-613 |
| checksum | A7255D54D42EFB88 |
| comment | FUNCTION Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed:17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed:22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed:23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed:31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.SUBUNIT Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1. Interacts with HSPA8; this interaction modulates migratory and antigen-presenting capacities of dendritic cells (PubMed:17785435).INTERACTION Colocalizes with CD81 at the immune synapse.ALTERNATIVE PRODUCTS Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells (PubMed:12708969). Expressed on dendritic cells (PubMed:17785435).DOMAIN The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.DOMAIN The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization. |
| created | [InstanceEdit:197813] de Bono, B, 2007-05-15 13:30:40 |
| description | recommendedName: Immunoglobulin superfamily member 8 shortName: IgSF8 alternativeName: CD81 partner 3 alternativeName: Glu-Trp-Ile EWI motif-containing protein 2 shortName: EWI-2 alternativeName: Keratinocytes-associated transmembrane protein 4 shortName: KCT-4 alternativeName: LIR-D1 alternativeName: Prostaglandin regulatory-like protein shortName: PGRL cdAntigenNameCD316/cdAntigenName |
| geneName | IGSF8 CD81P3 EWI2 KCT4 |
| identifier | Q969P0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IGSF8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994273] ENSEMBL:ENSG00000162729 IGSF8 [Homo sapiens] |
| secondaryIdentifier | IGSF8_HUMAN Q8NG09 Q96DP4 Q9BTG9 |
| sequenceLength | 613 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q969P0-1 |
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No pathways have been reviewed or authored by UniProt:Q969P0-1 IGSF8 (197798)
