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Details on Person UniProt:Q86WK6 AMIGO1
| Class:Id | ReferenceGeneProduct:197789 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-493 added on Fri February 6 2015 |
| _displayName | UniProt:Q86WK6 AMIGO1 |
| _timestamp | 2024-11-03 19:59:43 |
| chain | signal peptide:1-27 chain:28-493 |
| checksum | 8685B358570D9455 |
| comment | FUNCTION Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.SUBUNIT Homodimer, and heterodimer with AMIGO2 and AMIGO3. Interacts with KCNB1.INTERACTION Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells.DOMAIN The LRR repeat region mediates homodimerization.SIMILARITY Belongs to the immunoglobulin superfamily. AMIGO family. |
| created | [InstanceEdit:197813] de Bono, B, 2007-05-15 13:30:40 |
| description | recommendedName: Amphoterin-induced protein 1 alternativeName: AMIGO-1 alternativeName: Alivin-2 |
| geneName | AMIGO1 ALI2 AMIGO KIAA1163 |
| identifier | Q86WK6 |
| isSequenceChanged | FALSE |
| keyword | Cell adhesion Cell membrane Cell projection Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Leucine-rich repeat Membrane Neurogenesis Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AMIGO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992297] ENSEMBL:ENSG00000181754 AMIGO1 [Homo sapiens] |
| secondaryIdentifier | AMGO1_HUMAN B4DIM3 Q8IW71 Q9ULQ7 |
| sequenceLength | 493 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:197812] AMIGO1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q86WK6 AMIGO1 (197789)
