Query author contributions in Reactome

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Details on Person KIT [plasma membrane]

Class:Id	EntityWithAccessionedSequence:197662
_displayName	KIT [plasma membrane]
_timestamp	2021-07-27 18:44:49
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:197663] de Bono, B, 2007-05-14 15:28:49
endCoordinate	976
modified	[InstanceEdit:1433576] Garapati, P V, 2011-07-11 [InstanceEdit:1470082] Garapati, P V, 2011-08-02 [InstanceEdit:8981952] Jupe, Steve, 2017-03-15 [InstanceEdit:9748869] Orlic-Milacic, Marija, 2021-07-27
name	KIT Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT CD117
referenceEntity	[ReferenceGeneProduct:58103] UniProt:P10721 KIT [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591823] R-HSA-197662.3
startCoordinate	26
(hasComponent)	[Complex:205166] KIT:sSCF dimer [plasma membrane] [Homo sapiens] [Complex:205208] KIT:sSCF dimer:KIT [plasma membrane] [Homo sapiens] [Complex:1433419] PTPRU:KIT [plasma membrane] [Homo sapiens] [Complex:1433550] c-Kit:mSCF dimer [plasma membrane] [Homo sapiens] [Complex:8981948] IL33:IL1RL1:IL1RAP-1:KIT [plasma membrane] [Homo sapiens] [Complex:9669721] KIT:type II TKIs [plasma membrane] [Homo sapiens] [Complex:9681373] KIT:ripretinib [plasma membrane] [Homo sapiens]
(input)	[Reaction:205231] Dimerization of KIT upon SCF binding [Homo sapiens] [Reaction:205321] Interaction of KIT and sSCF [Homo sapiens] [Reaction:1433423] PTP-RO interacts with p-c-Kit complex [Homo sapiens] [Reaction:1433440] Interaction of c-Kit and mSCF [Homo sapiens] [Reaction:1433508] PKC alpha interacts with and phosphorylates KIT [Homo sapiens] [Reaction:8981740] IL33:IL1RL1:IL1RAP binds KIT [Homo sapiens] [Reaction:9669854] KIT binds type II TKIs [Homo sapiens] [Reaction:9681375] KIT binds ripretinib [Homo sapiens]
(marker)	[MarkerReference:9748822] c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture [MarkerReference:9748859] KIT [plasma membrane] Immunophenotypic profile of nucleated erythroid progenitors during maturation in regenerating bone marrow [MarkerReference:9827716] c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture [MarkerReference:9960442] KIT [plasma membrane] Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
(normalEntity)	[EntityFunctionalStatus:9669853] loss_of_function of dasatinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669860] loss_of_function of imatinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669864] loss_of_function of masitinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669866] loss_of_function of nilotinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669871] loss_of_function of regorafenib-resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669876] loss_of_function of sorafenib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669880] loss_of_function of sunitinib resistant KIT mutants [plasma membrane] [EntityFunctionalStatus:9669902] gain_of_function of type II TKI sensitive KIT mutants [plasma membrane] [EntityFunctionalStatus:9686617] gain_of_function of ripretinib-sensitive KIT mutants [plasma membrane]
(output)	[BlackBoxEvent:8864698] KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers [Homo sapiens]
(proteinMarker)	[Cell:9728467] proerythroblast [Homo sapiens] [Cell:9729101] melanocyte transit amplifying cell [Homo sapiens] [Cell:9729103] migratory trunk neural crest cell [Homo sapiens] [Cell:9729109] embryonic melanoblast [Homo sapiens] [Cell:9748724] erythroid burst-forming unit [Homo sapiens] [Cell:9748737] CFU-GM [Homo sapiens] [Cell:9927424] hormone receptor negative mammary luminal progenitor cell [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9897067] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v61:[addName] [_UpdateTracker:9902709] Update Tracker - [EntityWithAccessionedSequence:197662] KIT [plasma membrane] - v78:[addName]
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No pathways have been reviewed or authored by KIT [plasma membrane] (197662)