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Details on Person UniProt:O95256 IL18RAP
| Class:Id | ReferenceGeneProduct:197597 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-599 added on Fri February 6 2015 |
| _displayName | UniProt:O95256 IL18RAP |
| _timestamp | 2026-02-20 22:44:24 |
| chain | signal peptide:1-19 chain:20-599 |
| checksum | 54807DA3E05462F1 |
| comment | FUNCTION Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:14528293, PubMed:25500532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).CATALYTIC ACTIVITY NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)SUBUNIT Forms a ternary complex with IL18 and IL18R1 (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable).INTERACTION Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).INDUCTION Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.DOMAIN The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PTM N-glycosylated.SIMILARITY Belongs to the interleukin-1 receptor family. |
| created | [InstanceEdit:197592] de Bono, B, 2007-05-14 14:34:27 |
| description | recommendedName: Interleukin-18 receptor accessory protein shortName: IL-18 receptor accessory protein shortName: IL-18RAcP ecNumber evidence="3"3.2.2.6 alternativeName: Accessory protein-like shortName: AcPL alternativeName: CD218 antigen-like family member B alternativeName: CDw218b alternativeName: fullName evidence="11"IL-1R accessory protein-like shortName: IL-1RAcPL alternativeName: Interleukin-1 receptor 7 shortName: IL-1R-7 shortName: IL-1R7 alternativeName: Interleukin-18 receptor accessory protein-like alternativeName: fullName evidence="11 12 15"Interleukin-18 receptor beta shortName: IL-18R-beta shortName evidence="11 12 15"IL-18Rbeta cdAntigenNameCD218b/cdAntigenName |
| geneName | IL18RAP IL1R7 |
| identifier | O95256 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Hydrolase Immunoglobulin domain Inflammatory response Membrane NAD Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | IL18RAP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8980989] ENSEMBL:ENSG00000115607 IL18RAP [Homo sapiens] |
| secondaryIdentifier | I18RA_HUMAN B2RPJ3 Q2QDE5 Q3KPE7 Q3KPE8 Q53TT4 Q53TU5 |
| sequenceLength | 599 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970548] UniProt:O95256-1 IL18RAP [Homo sapiens] [ReferenceIsoform:8970549] UniProt:O95256-2 IL18RAP [Homo sapiens] [ReferenceIsoform:9027800] UniProt:O95256-3 IL18RAP [Homo sapiens] [ReferenceIsoform:9027801] UniProt:O95256-4 IL18RAP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197596] IL18RAP [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95256 IL18RAP (197597)
