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Details on Person NADSYN1 hexamer amidates NAAD to NAD+

Class:Id	Reaction:197271
_displayName	NADSYN1 hexamer amidates NAAD to NAD+
_doRelease	TRUE
_timestamp	2025-06-02 17:49:45
authored	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
catalystActivity	[CatalystActivity:197281] NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
crossReference	[DatabaseIdentifier:9937908] RHEA:24385
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
goBiologicalProcess	[GO_BiologicalProcess:262876] 'de novo' NAD+ biosynthetic process from L-tryptophan
input	[SimpleEntity:197256] NAAD [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29472] L-Gln [cytosol]
internalReviewed	[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
literatureReference	[LiteratureReference:197199] Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.
modified	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:8938087] Jassal, Bijay, 2016-09-08 [InstanceEdit:8939634] Jassal, Bijay, 2016-09-20 [InstanceEdit:8939813] Jassal, Bijay, 2016-09-21 [InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:8940091] Jassal, Bijay, 2016-09-23 [InstanceEdit:8943454] Jassal, Bijay, 2016-10-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07 [InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11 [InstanceEdit:9941781] D'Eustachio, Peter, 2025-03-10 [InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02
name	NADSYN1 hexamer amidates NAAD to NAD+ deamido-NAD(+) + L-glutamine + ATP + H2O => L-glutamate + AMP + diphosphate + NAD(+) + H(+) Amidation of deamino-NAD+ to NAD+
output	[SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens] [Reaction:197268] QPRT transfers PRIB to QUIN to form NAMN [Homo sapiens] [Reaction:197250] NAMPT transfers PRIB to NAM to form NAMN [Homo sapiens] [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN [Homo sapiens] [Reaction:8869607] NMRK2 phosphorylates NAR to yield NAMN [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2005-09-26
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361266] R-HSA-197271.5
structureModified	[InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07
summation	[Summation:197246] Cytosolic hexameric NAD synthase 1 (NADSYN1) catalyses the f...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ [Homo sapiens] [BlackBoxEvent:9961806] NAD+ translocates from the cytosol to the nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782434] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v59:[modifyText] [_UpdateTracker:9939742] Update Tracker - [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ - v92:[modifyText, removeOutput]
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