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Details on Person NAMPT transfers PRIB to NAM to form NAMN

Class:Id	Reaction:197250
_displayName	NAMPT transfers PRIB to NAM to form NAMN
_doRelease	TRUE
_timestamp	2025-07-17 06:44:44
authored	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
catalystActivity	[CatalystActivity:197240] nicotinamide phosphoribosyltransferase activity of NAMPT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
crossReference	[DatabaseIdentifier:9938163] RHEA:16151
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
input	[SimpleEntity:197277] NAM [cytosol] [SimpleEntity:73566] PRPP [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
literatureReference	[LiteratureReference:9938165] The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells [LiteratureReference:197216] Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
modified	[InstanceEdit:200480] D'Eustachio, P, 2007-07-19 16:12:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:8939813] Jassal, Bijay, 2016-09-21 [InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:8940091] Jassal, Bijay, 2016-09-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07 [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10 [InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11 [InstanceEdit:9953438] D'Eustachio, Peter, 2025-06-02 [InstanceEdit:9960863] May, Bruce, 2025-07-17
name	NAMPT transfers PRIB to NAM to form NAMN 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+) => beta-nicotinamide D-ribonucleotide + diphosphate Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)
output	[SimpleEntity:111294] PPi [cytosol] [SimpleEntity:8869359] NAMN [cytosol]
precedingEvent	[BlackBoxEvent:1368889] Expression of NAMPT (NamPRT, PBEF, Visfatin) [Homo sapiens] [Reaction:5663122] p-S90-BMAL1:p-T451,T461-CLOCK binds NAMPT gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2006-04-24
reviewed	[InstanceEdit:9953436] Hill, David P, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361426] R-HSA-197250.6
structureModified	[InstanceEdit:9937906] D'Eustachio, Peter, 2025-02-07 [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10
summation	[Summation:197253] Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens] [Reaction:200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens] [Reaction:200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939646] Update Tracker - [Reaction:197250] NAMPT transfers PRIB to NAM to form NAMN - v92:[add_removeOutput, modifyText, removeInput, removeLiteratureReference]
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