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Details on Person Chondroitin polymerase complex transfers GalNAc to CS chain

Class:Id	Reaction:1971487
_displayName	Chondroitin polymerase complex transfers GalNAc to CS chain
_doRelease	TRUE
_timestamp	2025-06-10 08:31:10
authored	[InstanceEdit:1971508] Jassal, B, 2011-11-04
catalystActivity	[CatalystActivity:1971459] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of Chondroitin polymerase complex [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1971508] Jassal, B, 2011-11-04
edited	[InstanceEdit:1971508] Jassal, B, 2011-11-04
input	[DefinedSet:2064050] chondroitin(2)-core proteins [Golgi lumen] [Homo sapiens] [SimpleEntity:735700] UDP-GalNAc [Golgi lumen]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:1971524] Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities [LiteratureReference:1971532] Chondroitin sulfate synthase-3. Molecular cloning and characterization [LiteratureReference:1971445] Molecular cloning and expression of a human chondroitin synthase [LiteratureReference:1971434] Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling [LiteratureReference:1971474] Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling [LiteratureReference:9941190] Biosynthesis and function of chondroitin sulfate [URL:9955245] https://doi.org/10.1101/2025.03.21.644485
modified	[InstanceEdit:2018689] Jassal, B, 2011-11-24 [InstanceEdit:2022912] Jassal, B, 2011-12-01 [InstanceEdit:2024092] Jassal, B, 2011-12-14 [InstanceEdit:2063989] Jassal, B, 2012-01-18 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:5607542] Jassal, Bijay, 2014-07-11 [InstanceEdit:9632032] Jassal, Bijay, 2018-12-13 [InstanceEdit:9774098] D'Eustachio, Peter, 2022-05-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12 [InstanceEdit:9955241] Stephan, Ralf, 2025-06-10
name	Chondroitin polymerase complex transfers GalNAc to CS chain GalNAc is added to chondroitin
output	[SimpleEntity:205687] UDP [Golgi lumen] [DefinedSet:2064075] chondroitin(3)-core proteins [Golgi lumen] [Homo sapiens] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:1971491] Chondroitin polymerase complex transfers GlcA to CS chain [Homo sapiens] [Reaction:1971482] CSGALNACTs transfer GalNAc to CS linker glycan [Homo sapiens] [Reaction:735702] SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295092] R-HSA-1971487.6
structureModified	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation	[Summation:1971503] The chondroitin polymerase complex transfers one GalNAc moie...
(hasEvent)	[Pathway:2022870] CS-GAG biosynthesis [Homo sapiens]
(normalReaction)	[FailedReaction:3595176] Defective CHSY1 does not transfer GalNAc to chondroitin [Homo sapiens]
(precedingEvent)	[Reaction:1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc [Homo sapiens] [Reaction:2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953697] Update Tracker - [Reaction:1971487] Chondroitin polymerase complex transfers GalNAc to CS chain - v93:[modifyText, removeLiteratureReference, removeOutput] [_UpdateTracker:9964785] Update Tracker - [Reaction:1971487] Chondroitin polymerase complex transfers GalNAc to CS chain - v94:[modifyText, removeLiteratureReference]
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