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Details on Person CSGALNACTs transfer GalNAc to CS linker glycan

Class:IdReaction:1971482
_displayNameCSGALNACTs transfer GalNAc to CS linker glycan
_doReleaseTRUE
_timestamp2025-03-12 10:00:19
authored[InstanceEdit:1971508] Jassal, B, 2011-11-04
catalystActivity[CatalystActivity:1971478] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of CSGALNACT [Golgi membrane]
compartment[Compartment:20699] Golgi membrane
[Compartment:17963] Golgi lumen
created[InstanceEdit:1971508] Jassal, B, 2011-11-04
crossReference[DatabaseIdentifier:9941001] RHEA:23465
edited[InstanceEdit:1971508] Jassal, B, 2011-11-04
input[SimpleEntity:735700] UDP-GalNAc [Golgi lumen]
[DefinedSet:2064233] GlcA-Gal-Gal-Xyl-CS proteins [Golgi lumen] [Homo sapiens]
internalReviewed[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimericFALSE
literatureReference[LiteratureReference:1971473] Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate
[LiteratureReference:1971460] Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis
[LiteratureReference:9941057] Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity
modified[InstanceEdit:2018658] Jassal, B, 2011-11-24
[InstanceEdit:2018689] Jassal, B, 2011-11-24
[InstanceEdit:2063989] Jassal, B, 2012-01-18
[InstanceEdit:2161486] Jassal, B, 2012-03-14
[InstanceEdit:2162219] Jassal, B, 2012-03-16
[InstanceEdit:2247519] Jassal, B, 2012-05-14
[InstanceEdit:2428935] Jassal, B, 2012-08-09
[InstanceEdit:9774098] D'Eustachio, Peter, 2022-05-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
[InstanceEdit:9941987] Stephan, Ralf, 2025-03-12
[InstanceEdit:9941990] Stephan, Ralf, 2025-03-12
nameCSGALNACTs transfer GalNAc to CS linker glycan
The addition of GalNAc to the terminal glucuronate residue forms chondroitin
output[SimpleEntity:205687] UDP [Golgi lumen]
[DefinedSet:2064172] chondroitin(1)-core proteins [Golgi lumen] [Homo sapiens]
[SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2012-06-12
reviewed[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
[InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294669] R-HSA-1971482.4
structureModified[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation[Summation:1971510] Chondroitin sulfate N-acetylgalactosaminyltransferases 1 and...
(hasEvent)[Pathway:2022870] CS-GAG biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:1971491] Chondroitin polymerase complex transfers GlcA to CS chain [Homo sapiens]
[Reaction:9632034] CHSY1 transfers GlcA to chondroitin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9953602] Update Tracker - [Reaction:1971482] CSGALNACTs transfer GalNAc to CS linker glycan - v93:[modifyText, removeLiteratureReference, removeOutput]
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No pathways have been reviewed or authored by CSGALNACTs transfer GalNAc to CS linker glycan (1971482)
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