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Details on Person PANK2 phosphorylates PanK

Class:Id	Reaction:196857
_displayName	PANK2 phosphorylates PanK
_doRelease	TRUE
_timestamp	2023-07-26 14:30:22
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:196799] pantothenate kinase activity of PANK2(141-570) [mitochondrial intermembrane space]
compartment	[Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
input	[SimpleEntity:196820] PanK [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:196762] An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria [LiteratureReference:196739] Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration [LiteratureReference:199239] Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine [LiteratureReference:9837293] Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters [LiteratureReference:196771] Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration [LiteratureReference:199209] A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
modified	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52 [InstanceEdit:197283] Jassal, B, 2007-05-02 10:05:07 [InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12 [InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:3165246] Jassal, B, 2013-02-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12 [InstanceEdit:9840789] D'Eustachio, Peter, 2023-07-26
name	PANK2 phosphorylates PanK (R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)
output	[SimpleEntity:196786] PPanK [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9837290] Negative regulation by 'CoA-SH [cytosol]'
regulationReference	[RegulationReference:9837286] Negative regulation by 'CoA-SH [cytosol]' Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
releaseDate	2007-09-04
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361125] R-HSA-196857.4
structureModified	[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
summation	[Summation:196776] Pantothenate kinase 2 (PANK2) catalyzes the reaction of ATP ...
(hasEvent)	[Pathway:196783] Coenzyme A biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:196753] 2xPPCS ligates PPanK with Cys [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842331] Update Tracker - [Reaction:196857] PANK2 phosphorylates PanK - v86:[addLiteratureReference, addOutput, addRegulator, modifyText]
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