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Details on Person 3xPPCDC:3FMN decarboxylates PPC

Class:Id	Reaction:196840
_displayName	3xPPCDC:3FMN decarboxylates PPC
_doRelease	TRUE
_timestamp	2023-07-26 14:30:18
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:196842] phosphopantothenoylcysteine decarboxylase activity of 3xPPCDC:3xFMN [cytosol]
catalystActivityReference	[CatalystActivityReference:9837292] phosphopantothenoylcysteine decarboxylase activity of 3xPPCDC:3xFMN [cytosol] Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
input	[SimpleEntity:196834] PPC [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:196746] Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics [LiteratureReference:196789] Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent
modified	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52 [InstanceEdit:197283] Jassal, B, 2007-05-02 10:05:07 [InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12 [InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:3165246] Jassal, B, 2013-02-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12 [InstanceEdit:9840789] D'Eustachio, Peter, 2023-07-26
name	3xPPCDC:3FMN decarboxylates PPC (R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate
output	[SimpleEntity:196767] PPANT [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:196753] 2xPPCS ligates PPanK with Cys [Homo sapiens] [Reaction:196857] PANK2 phosphorylates PanK [Homo sapiens] [Reaction:199203] PANK1/3 phosphorylate PanK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2006-04-24
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360217] R-HSA-196840.4
structureModified	[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
summation	[Summation:196750] The decarboxylation of phosphopantothenoylcysteine (PPC) to ...
(hasEvent)	[Pathway:196783] Coenzyme A biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:196754] COASY transfers an adenylyl group from ATP to PPANT [Homo sapiens] [Reaction:9837419] PANK4 hydrolyzes PPANT to pantetheine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787567] Update Tracker - [Reaction:196840] 3xPPCDC:3FMN decarboxylates PPC - v44:[modifyText] [_UpdateTracker:9842356] Update Tracker - [Reaction:196840] 3xPPCDC:3FMN decarboxylates PPC - v86:[addInput, modifyText]
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