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Details on Person COASY transfers an adenylyl group from ATP to PPANT

Class:Id	Reaction:196754
_displayName	COASY transfers an adenylyl group from ATP to PPANT
_doRelease	TRUE
_timestamp	2023-07-26 14:30:19
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:196830] pantetheine-phosphate adenylyltransferase activity of COASY [mitochondrial outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:196767] PPANT [cytosol]
literatureReference	[LiteratureReference:196745] Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase) [LiteratureReference:196824] Subcellular localization and regulation of coenzyme A synthase
modified	[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52 [InstanceEdit:197283] Jassal, B, 2007-05-02 10:05:07 [InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12 [InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23 [InstanceEdit:732460] D'Eustachio, P, 2010-05-12 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:3165246] Jassal, B, 2013-02-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9837348] D'Eustachio, Peter, 2023-06-13 [InstanceEdit:9840789] D'Eustachio, Peter, 2023-07-26
name	COASY transfers an adenylyl group from ATP to PPANT (R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate Adenylation of phosphopantetheine
output	[SimpleEntity:196778] DP-CoA [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:196840] 3xPPCDC:3FMN decarboxylates PPC [Homo sapiens] [Reaction:196753] 2xPPCS ligates PPanK with Cys [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-09-26
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358825] R-HSA-196754.4
structureModified	[InstanceEdit:9837348] D'Eustachio, Peter, 2023-06-13
summation	[Summation:196826] The adenylyl transferase activity of bifunctional coenzyme A...
(hasEvent)	[Pathway:196783] Coenzyme A biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:196773] COASY phosphorylates DP-CoA [Homo sapiens] [Reaction:9837337] DCAKD phosphorylates DP-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787971] Update Tracker - [Reaction:196754] COASY transfers an adenylyl group from ATP to PPANT - v44:[modifyText] [_UpdateTracker:9842315] Update Tracker - [Reaction:196754] COASY transfers an adenylyl group from ATP to PPANT - v86:[addInput]
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