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Details on Person 2xPPCS ligates PPanK with Cys

Class:IdReaction:196753
_displayName2xPPCS ligates PPanK with Cys
_doReleaseTRUE
_timestamp2023-07-26 14:30:17
authored[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity[CatalystActivity:196734] phosphopantothenate--cysteine ligase activity of 2xPPCS [cytosol]
catalystActivityReference[CatalystActivityReference:9837295] phosphopantothenate--cysteine ligase activity of 2xPPCS [cytosol] Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics
compartment[Compartment:70101] cytosol
created[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
input[SimpleEntity:196786] PPanK [cytosol]
[SimpleEntity:111707] L-Cys [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:196746] Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics
[LiteratureReference:199225] Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
modified[InstanceEdit:197203] Jassal, B, 2007-05-02 09:36:52
[InstanceEdit:197283] Jassal, B, 2007-05-02 10:05:07
[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
[InstanceEdit:200987] Gopinathrao, G, 2007-07-27 15:28:23
[InstanceEdit:732460] D'Eustachio, P, 2010-05-12
[InstanceEdit:3165246] Jassal, B, 2013-02-22
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
[InstanceEdit:9840789] D'Eustachio, Peter, 2023-07-26
name2xPPCS ligates PPanK with Cys
(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-((R)-4-phosphopantothenoyl)-L-cysteine
output[SimpleEntity:196834] PPC [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2006-01-23
reviewed[InstanceEdit:9840788] Hill, David P, 2023-07-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361808] R-HSA-196753.4
structureModified[InstanceEdit:9837287] D'Eustachio, Peter, 2023-06-12
summation[Summation:196821] The conjugation of cysteine (Cys) and 4'- phosphopantothenat...
(hasEvent)[Pathway:196783] Coenzyme A biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:196840] 3xPPCDC:3FMN decarboxylates PPC [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787548] Update Tracker - [Reaction:196753] 2xPPCS ligates PPanK with Cys - v44:[modifyText]
[_UpdateTracker:9842231] Update Tracker - [Reaction:196753] 2xPPCS ligates PPanK with Cys - v86:[addOutput]
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