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Details on Person heparan sulfate proteoglycan biosynthetic process

Class:Id	GO_BiologicalProcess:19668
_displayName	heparan sulfate proteoglycan biosynthetic process
_timestamp	2009-11-21 18:35:24
accession	0015012
definition	The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
modified	[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35 [InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09 [InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16 [InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20 [InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39 [InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04 [InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44 [InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57 [InstanceEdit:422569] Kanapin, EE [InstanceEdit:436347] Kanapin, EE [InstanceEdit:447572] Kanapin, EE [InstanceEdit:526073] Kanapin, AA [InstanceEdit:528085] Kanapin, AA [InstanceEdit:615500] Kanapin, AA [InstanceEdit:797782] Kanapin, AA [InstanceEdit:937668] Yung, CK [InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266118] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name	heparan sulfate proteoglycan biosynthetic process
referenceDatabase	[ReferenceDatabase:1] GO
(goBiologicalProcess)	[Reaction:2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain [Homo sapiens] [Reaction:2022856] EXT1:EXT2 transfers GlcA to heparan [Homo sapiens] [Reaction:2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) [Homo sapiens] [Reaction:2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan [Homo sapiens] [Pathway:2022928] HS-GAG biosynthesis [Homo sapiens] [Reaction:2024100] GLCE epimerises GlcA to IdoA [Homo sapiens] [Reaction:2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises [Homo sapiens] [Reaction:2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076392] EXT1:EXT2 transfers GlcA to heparan [Homo sapiens] [Reaction:2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin [Homo sapiens] List all 13 refering instances
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No pathways have been reviewed or authored by heparan sulfate proteoglycan biosynthetic process (19668)