Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The human genome includes approximately 70 genes that are pr...
| Class:Id | Summation:196637 |
|---|---|
| _displayName | The human genome includes approximately 70 genes that are pr... |
| _timestamp | 2018-05-23 17:03:34 |
| created | [InstanceEdit:196630] Gopinathrao, G, 2007-04-23 20:29:15 |
| literatureReference | [LiteratureReference:195241] Current knowledge of the large RhoGAP family of proteins [LiteratureReference:196666] GTPase signaling: bridging the GAP between ARF and Rho |
| modified | [InstanceEdit:196706] Gopinathrao, G, 2007-04-23 21:00:56 [InstanceEdit:196726] Gopinathrao, G, 2007-04-24 02:36:54 [InstanceEdit:197003] D'Eustachio, P, 2007-04-28 21:22:45 [InstanceEdit:9609398] D'Eustachio, Peter, 2018-05-23 |
| text | The human genome includes approximately 70 genes that are predicted to encode Rho-specific GTPase Activating Proteins (RhoGAPs). As in the case of GEFs, some RhoGAPs are believed to be highly specific, whereas others are more promiscuous with respect to their target GTPases. Increasing evidence suggests that GAPs are also regulated by external cues in addition to being signal terminators leading to Rho GTPase inactivation. These proteins play important role in many Rho mediated signaling pathways. Some known GAPs include p190 A, cdGAP, ARAP3, MgcRacGAP, Chimaerin, Nadrin, TCGAP, DLC 1, 2, ArhGAP6, Myosin IXA. These and other GAPs have been implicated in many processes, such as exocytosis, endocytosis, cytokinesis, cell differentiation, migration, neuronal morphogenesis, angiogenesis and tumor suppression. |
| [Change default viewing format] | |
