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Details on Person Guanine nucleotide exchange factors (GEFs) activate GTPases ...

Class:IdSummation:196548
_displayNameGuanine nucleotide exchange factors (GEFs) activate GTPases ...
_timestamp2009-05-05 12:43:25
created[InstanceEdit:196526] Gopinathrao, G, 2007-04-23 11:41:47
literatureReference[LiteratureReference:195238] Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
[LiteratureReference:196549] Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
[LiteratureReference:196525] Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
modified[InstanceEdit:196706] Gopinathrao, G, 2007-04-23 21:00:56
[InstanceEdit:197003] D'Eustachio, P, 2007-04-28 21:22:45
[InstanceEdit:419643] Jupe, S, 2009-05-05 12:44:28
textGuanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).
(summation)[Reaction:419166] GEFs activate RhoA,B,C [Homo sapiens]
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