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Details on Person 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol

Class:Id	Reaction:196372
_displayName	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
_doRelease	TRUE
_timestamp	2008-11-17 10:20:42
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:196330] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193124] 17aHPREG [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:192183] Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells [LiteratureReference:196332] Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes [LiteratureReference:196346] Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads [LiteratureReference:196356] Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
modified	[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol 17-hydroxypregnenolone + NAD+ => pregn-5-ene-3,20-dione-17-ol + NADH + H+
output	[SimpleEntity:196366] pregn-5-ene-3,20-dione-17-ol [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:193068] CYP17A1 17-hydroxylates PREG [Homo sapiens] [BlackBoxEvent:193097] Pregnenolone translocates from the mitochondrial matrix to the cytosol [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361740] R-HSA-196372.2
summation	[Summation:196369] 17-Hydroxypregnenolone and NAD+ react to form pregn-5-ene-3,...
(hasEvent)	[Pathway:194002] Glucocorticoid biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:193961] Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone [Homo sapiens]
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