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Details on Person ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4

Class:Id	Reaction:1963589
_displayName	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
_doRelease	TRUE
_timestamp	2019-11-01 03:10:45
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[DefinedSet:1963571] Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] [Homo sapiens] [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248735] Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation [LiteratureReference:1227977] Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90 [LiteratureReference:1227978] Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex [LiteratureReference:1358720] ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor [LiteratureReference:1228001] Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function [LiteratureReference:1227996] ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer [LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions [LiteratureReference:1250122] Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners
modified	[InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:2008068] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:9634294] Orlic-Milacic, Marija, 2019-01-09 [InstanceEdit:9665907] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9665984] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
output	[DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1247497] ERBB3 binds neuregulins [Homo sapiens] [Reaction:177942] EGFR binds EGF ligand [Homo sapiens] [Reaction:177946] Pro-EGF is cleaved to form mature EGF [Homo sapiens] [Reaction:1236398] ERBB4 binds NRGs or EGF-like ligands [Homo sapiens] [Reaction:1227971] Association of mature ERBB2 with HSP90 chaperone and its co-chaperone CDC37 [Homo sapiens]
regulatedBy	[NegativeRegulation:9665972] Negative regulation by 'ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane]'
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016327] R-HSA-1963589.4
summation	[Summation:1963564] ERBB2, which does not bind any known ligand, is activated th...
(hasEvent)	[Pathway:1227986] Signaling by ERBB2 [Homo sapiens]
(normalReaction)	[Reaction:9664567] ERBB2 KD mutants heterodimerize [Homo sapiens] [Reaction:9665388] ERBB2 ECD mutants heterodimerize with EGFR [Homo sapiens] [Reaction:9665697] ERBB2 TMD/JMD mutants hetrodimerize [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9866018] Futile Cycle: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777423] Update Tracker - [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - v71:[addRegulator] [_UpdateTracker:9777629] Update Tracker - [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - v70:[modifyText]
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