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Details on Person p-ERBB2 heterodimers [plasma membrane]
| Class:Id | CandidateSet:1963588 |
| _displayName | p-ERBB2 heterodimers [plasma membrane] |
| _timestamp | 2016-10-11 13:08:25 |
| compartment | [Compartment:876] plasma membrane |
| created | [InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03 |
| hasCandidate |
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| hasMember |
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| modified | [InstanceEdit:5673683] Weiser, JD [InstanceEdit:6785655] Orlic-Milacic, Marija, 2015-06-29 [InstanceEdit:6792437] Weiser, JD [InstanceEdit:8942261] Orlic-Milacic, Marija, 2016-10-11 |
| name | p-ERBB2 heterodimers Phosphorylated ERBB2 heterodimers |
| species | [Species:48887] Homo sapiens |
| stableIdentifier | [StableIdentifier:2016944] R-HSA-1963588.3 |
| (hasComponent) | [Complex:1248746] SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens] [Complex:1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens] [Complex:1963590] p-ERBB2 heterodimers:MATK [plasma membrane] [Homo sapiens] [Complex:6785640] p-ERBB2 heterodimers:MEMO1 [plasma membrane] [Homo sapiens] [Complex:8848002] p-ERBB2 heterodimers:PTK6 [plasma membrane] [Homo sapiens] |
| (input) | [Reaction:1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 [Homo sapiens] [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers [Homo sapiens] [Reaction:6785636] Phosphorylated ERBB2 heterodimers bind MEMO1 [Homo sapiens] [Reaction:8847995] Activated ERBB2 binds PTK6 (BRK) [Homo sapiens] [Reaction:8863804] PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [Homo sapiens] |
| (normalEntity) | [EntityFunctionalStatus:9655369] gain_of_function of Phosphorylated ERBB2 L755S,(ERBB2 L755M,ERBB2 L755W) heterodimers [plasma membrane] [EntityFunctionalStatus:9655383] gain_of_function of Phosphorylated ERBB2 L755P heterodimers [plasma membrane] [EntityFunctionalStatus:9655448] gain_of_function of Phosphorylated ERBB2 R896C,(ERBB2 R896H) heterodimers [plasma membrane] [EntityFunctionalStatus:9655449] increased_translational_product_level of p-ERBB2 homodimer [plasma membrane] [EntityFunctionalStatus:9655450] gain_of_function of Phosphorylated ERBB2 D769H,(ERBB2 D769Y,ERBB2 D769N) heterodimers [plasma membrane] [EntityFunctionalStatus:9655451] gain_of_function of Phosphorylated ERBB2 T798I,ERBB2 T798M,(ERBB2 T733I) heterodimers [plasma membrane] [EntityFunctionalStatus:9655452] gain_of_function of Phosphorylated ERBB2 I767M heterodimers [plasma membrane] [EntityFunctionalStatus:9655453] gain_of_function of Phosphorylated ERBB2 V842I,(ERBB2 V842E) heterodimers [plasma membrane] [EntityFunctionalStatus:9655454] gain_of_function of Phosphorylated ERBB2 T862A heterodimers [plasma membrane] [EntityFunctionalStatus:9655455] gain_of_function of Phosphorylated ERBB2 V777L,(ERBB2 V777M,ERBB2 V777E) heterodimers [plasma membrane] |
| (output) | [Reaction:8848005] ERBB2 promotes PTK6 autophosphorylation [Homo sapiens] |
| (updatedInstance) | [_UpdateTracker:9872143] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v41:[updateContainedMemberOrCandidate] [_UpdateTracker:9873026] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate] [_UpdateTracker:9879858] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v44:[updateContainedMemberOrCandidate] [_UpdateTracker:9888332] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v46:[updateContainedMemberOrCandidate] [_UpdateTracker:9892778] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v54:[addName] [_UpdateTracker:9894674] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v57:[updateContainedMemberOrCandidate] [_UpdateTracker:9895592] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v59:[removeCompartment] [_UpdateTracker:9900870] Update Tracker - [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] - v70:[updateContainedMemberOrCandidate] |
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No pathways have been reviewed or authored by p-ERBB2 heterodimers [plasma membrane] (1963588)