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Details on Person Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]

Class:IdCandidateSet:1963587
_displayNamePhosphorylated ERBB2:EGFR heterodimers [plasma membrane]
_timestamp2012-08-13 11:29:31
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
hasCandidate
hasMember
modified[InstanceEdit:2000336] Orlic-Milacic, M, 2011-11-21
[InstanceEdit:2448604] Orlic-Milacic, M, 2012-08-13
namePhosphorylated ERBB2:EGFR heterodimers
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2018077] R-HSA-1963587.1
(hasComponent)[Complex:1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] [Homo sapiens]
[Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] [Homo sapiens]
[Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] [Homo sapiens]
[Complex:1985735] Shc1:Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] [Homo sapiens]
[Complex:8864106] Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] [Homo sapiens]
(input)[Reaction:1248744] Shc1 binds phosphorylated ERBB2:EGFR heterodimers [Homo sapiens]
[Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens]
[Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens]
[Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Homo sapiens]
[Reaction:8864105] PTPN18 binds ERBB2:EGFR heterodimers [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:9655362] gain_of_function of EGF:p-6Y-EGFR:p-6Y-ERBB2 L755S,(p-6Y-ERBB2 L755M,p-6Y-ERBB2 L755W) [plasma membrane]
[EntityFunctionalStatus:9655382] gain_of_function of Phosphorylated ERBB2 L755P:EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655430] gain_of_function of Phosphorylated ERBB2 T798I,ERBB2 T798M,(ERBB2 T733I):EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655431] gain_of_function of Phosphorylated ERBB2 V777L,(ERBB2 V777M,ERBB2 V777E):EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655433] gain_of_function of Phosphorylated ERBB2 H878Y,(ERBB2 H878R):EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655434] gain_of_function of Phosphorylated ERBB2 I767M:EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655435] gain_of_function of Phosphorylated ERBB2 T862A:EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655436] gain_of_function of Phosphorylated ERBB2 P780_Y781insGSP:EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655664] gain_of_function of Phosphorylated ERBB2 D769H,(ERBB2 D769Y,ERBB2 D769N):EGFR heterodimer [plasma membrane]
[EntityFunctionalStatus:9655666] gain_of_function of Phosphorylated ERBB2 R896C,(ERBB2 R896H):EGFR heterodimer [plasma membrane]
List all 18 refering instances
(output)[Reaction:1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9872089] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v41:[updateContainedMemberOrCandidate]
[_UpdateTracker:9872946] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v42:[removeCompartment]
[_UpdateTracker:9879418] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v44:[updateContainedMemberOrCandidate]
[_UpdateTracker:9894632] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v57:[updateContainedMemberOrCandidate]
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No pathways have been reviewed or authored by Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (1963587)
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