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Details on Person Trans-autophosphorylation of ERBB2 heterodimers

Class:Id	Reaction:1963582
_displayName	Trans-autophosphorylation of ERBB2 heterodimers
_doRelease	TRUE
_timestamp	2019-10-30 13:39:18
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1963566] protein tyrosine kinase activity of ERBB2 heterodimers [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248697] Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase [LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions [LiteratureReference:189936] Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates [LiteratureReference:189933] All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. [LiteratureReference:1248688] Identification of autophosphorylation sites of HER2/neu [LiteratureReference:179793] Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines [LiteratureReference:1250122] Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners [LiteratureReference:1250127] Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera [LiteratureReference:1250125] Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling [LiteratureReference:1678599] Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3 [LiteratureReference:1250297] System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties [LiteratureReference:1250306] HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers
modified	[InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:1986602] Orlic-Milacic, M, 2011-11-11 [InstanceEdit:9652372] Orlic-Milacic, Marija, 2019-06-28 [InstanceEdit:9665224] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Trans-autophosphorylation of ERBB2 heterodimers
output	[DefinedSet:1963585] p-6Y-ERBB2 heterodimers [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1247497] ERBB3 binds neuregulins [Homo sapiens] [Reaction:177942] EGFR binds EGF ligand [Homo sapiens] [Reaction:1236398] ERBB4 binds NRGs or EGF-like ligands [Homo sapiens] [Reaction:1227971] Association of mature ERBB2 with HSP90 chaperone and its co-chaperone CDC37 [Homo sapiens]
regulatedBy	[NegativeRegulation:9652363] Negative regulation by 'ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]' [NegativeRegulation:9652348] Negative regulation by 'ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]'
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016610] R-HSA-1963582.4
summation	[Summation:1963576] Dimers of ERBB2 and EGF-bound EGFR trans-autophosphorylate o...
(hasEvent)	[Pathway:1227986] Signaling by ERBB2 [Homo sapiens]
(normalReaction)	[Reaction:1248694] Trans-autophosphorylation of ERBB2 homodimer [Homo sapiens] [Reaction:9647036] ERBB2 KD mutant heterodimers trans-autophosphorylate [Homo sapiens] [Reaction:9664588] ERBB2 KD mutants trans-autophosphorylate [Homo sapiens] [Reaction:9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate [Homo sapiens] [Reaction:9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate [Homo sapiens]
(precedingEvent)	[Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens] [Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens] [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens] [Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 [Homo sapiens] [Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers [Homo sapiens] [Reaction:1358798] RNF41 binds neuregulin-activated ERBB3 [Homo sapiens] [Reaction:1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 [Homo sapiens] [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers [Homo sapiens] List all 14 refering instances
(updatedInstance)	[_UpdateTracker:9777458] Update Tracker - [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers - v71:[add_removeRegulator] [_UpdateTracker:9777617] Update Tracker - [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers - v70:[addRegulator, modifyText]
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