Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Trans-autophosphorylation of p-Y877-ERBB2 heterodimers

Class:IdReaction:1963581
_displayNameTrans-autophosphorylation of p-Y877-ERBB2 heterodimers
_doReleaseTRUE
_timestamp2011-11-23 11:07:31
authored[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity[CatalystActivity:1963577] protein tyrosine kinase activity of p-Y877-ERBB2 heterodimers [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
edited[InstanceEdit:1816717] D'Eustachio, P, 2011-10-25
input[DefinedSet:1963584] p-Y877-ERBB2 heterodimers [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1810436] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
modified[InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTrans-autophosphorylation of p-Y877-ERBB2 heterodimers
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[DefinedSet:1963580] Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2011-12-06
reviewed[InstanceEdit:1972347] Neckers, LM, 2011-11-11
[InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2016225] R-HSA-1963581.2
summation[Summation:1963570] Phosphorylation of ERBB2 on tyrosine residue Y877 by SRC fam...
(hasEvent)[Pathway:1227986] Signaling by ERBB2 [Homo sapiens]
(precedingEvent)[Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens]
[Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens]
[Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens]
[Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens]
[Reaction:1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 [Homo sapiens]
[Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Homo sapiens]
[Reaction:1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers [Homo sapiens]
[Reaction:1358798] RNF41 binds neuregulin-activated ERBB3 [Homo sapiens]
[Reaction:1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 [Homo sapiens]
[Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers [Homo sapiens]
List all 14 refering instances
[Change default viewing format]
No pathways have been reviewed or authored by Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (1963581)