Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
Class:Id Reaction:1963581
_displayName Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
_doRelease TRUE
_timestamp 2011-11-23 11:07:31
authored [InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity [CatalystActivity:1963577] protein tyrosine kinase activity of p-Y877-ERBB2 heterodimers [plasma membrane]
compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created [InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
edited [InstanceEdit:1816717] D'Eustachio, P, 2011-10-25
input [DefinedSet:1963584] p-Y877-ERBB2 heterodimers [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric FALSE
literatureReference [LiteratureReference:1810436] Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
modified [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [DefinedSet:1963580] Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate 2011-12-06
reviewed [InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:2016225] R-HSA-1963581.2
summation [Summation:1963570] Phosphorylation of ERBB2 on tyrosine residue Y877 by SRC fam...
(hasEvent) [Pathway:1227986] Signaling by ERBB2 [Homo sapiens]
(precedingEvent) [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens] [Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens] [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens] [Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 [Homo sapiens] [Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers [Homo sapiens] [Reaction:1358798] RNF41 binds neuregulin-activated ERBB3 [Homo sapiens] [Reaction:1963563] MATK (CSK homologous kinase) binds phosphorylated ERBB2 [Homo sapiens] [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers [Homo sapiens]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (1963581)