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Details on Person SHC1 binds phosphorylated ERBB2 heterodimers

Class:Id	Reaction:1963578
_displayName	SHC1 binds phosphorylated ERBB2 heterodimers
_doRelease	TRUE
_timestamp	2024-03-20 23:47:13
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
inferredFrom	[Reaction:1248753] Shc1 binds phosphorylated ERBB2:ERBB3 heterodimers [Homo sapiens] [Reaction:1248744] Shc1 binds phosphorylated ERBB2:EGFR heterodimers [Homo sapiens]
input	[EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens] [CandidateSet:1963588] p-ERBB2 heterodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions [LiteratureReference:1250297] System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties [LiteratureReference:1250306] HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers [LiteratureReference:8863803] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
modified	[InstanceEdit:1972363] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:8864026] Orlic-Milacic, Marija, 2016-03-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	SHC1 binds phosphorylated ERBB2 heterodimers
negativePrecedingEvent	[NegativePrecedingEvent:9866052] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866038] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866049] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
output	[Complex:1248746] SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens] [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens]
regulatedBy	[NegativeRegulation:8864022] Negative regulation by 'PTPN12 [cytosol]'
regulationReference	[RegulationReference:9641889] Negative regulation by 'PTPN12 [cytosol]' Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016591] R-HSA-1963578.6
summation	[Summation:1963574] SHC1 binds phosphorylated ERBB2:EGFR heterodimers through ph...
(hasEvent)	[Pathway:1250196] SHC1 events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9634391] SHC1 binds phosphorylated ERBB2 homodimer [Homo sapiens] [Reaction:9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 [Homo sapiens] [Reaction:9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 [Homo sapiens] [Reaction:9665701] Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 [Homo sapiens]
(precedingEvent)	[Reaction:1250195] SHC1 phosphorylation by ERBB2 heterodimers [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777560] Update Tracker - [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers - v70:[modifyText] [_UpdateTracker:9783191] Update Tracker - [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers - v57:[addLiteratureReference, addRegulator, modifyText]
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No pathways have been reviewed or authored by SHC1 binds phosphorylated ERBB2 heterodimers (1963578)