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Details on Person Dissociation of HSP90 from ERBB2 upon formation of ERBB2 het...
| Class:Id | Summation:1963575 |
|---|---|
| _displayName | Dissociation of HSP90 from ERBB2 upon formation of ERBB2 het... |
| _timestamp | 2011-11-03 20:31:43 |
| created | [InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03 |
| text | Dissociation of HSP90 from ERBB2 upon formation of ERBB2 heterodimers (with either EGFR, ERBB3 or ERBB4) enables phosphorylation of ERBB2 on the tyrosine residue Y877, mediated by one of SRC family kinases - SRC, FYN or YES1. Although not a mandatory prerequisite of ERBB2 catalytic activity, the phosphorylation at Y877 significantly increases the kinase activity of ERBB2. |
| (summation) | [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens] |
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No pathways have been reviewed or authored by Dissociation of HSP90 from ERBB2 upon formation of ERBB2 het... (1963575)
