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Details on Person ERBB2 heterodimers [plasma membrane]

Class:Id	DefinedSet:1963573
_displayName	ERBB2 heterodimers [plasma membrane]
_timestamp	2013-08-28 16:53:19
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03
hasMember	[Complex:1227939] EGF:EGFR:ERBB2 [plasma membrane] [Homo sapiens] [Complex:1247502] NRG1/2:ERBB3:ERBB2 [plasma membrane] [Homo sapiens] [DefinedSet:1250224] NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] [Homo sapiens] [Complex:1250328] ERBB2:ERBB4cyt1 heterodimers [plasma membrane] [Homo sapiens] [Complex:1250312] ERBB2:ERBB4cyt2 heterodimer [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:4419921] Orlic-Milacic, M, 2013-08-28
name	ERBB2 heterodimers
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016948] R-HSA-1963573.1
(input)	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9647045] gain_of_function of ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] [EntityFunctionalStatus:9655359] gain_of_function of ERBB2 L755S,(ERBB2 L755M,ERBB2 L755W) heterodimers [plasma membrane] [EntityFunctionalStatus:9655372] loss_of_function of ERBB2 L755S heterodimers [plasma membrane] [EntityFunctionalStatus:9655385] gain_of_function of ERBB2 L755P heterodimers [plasma membrane] [EntityFunctionalStatus:9655391] gain_of_function of ERBB2 P780_Y781insGSP heterodimers [plasma membrane] [EntityFunctionalStatus:9655392] gain_of_function of ERBB2 I767M heterodimers [plasma membrane] [EntityFunctionalStatus:9655394] gain_of_function of ERBB2 L869R,(ERBB2 L869Q) heterodimers [plasma membrane] [EntityFunctionalStatus:9655395] gain_of_function of ERBB2 R896C,(ERBB2 R896H) heterodimers [plasma membrane] [EntityFunctionalStatus:9655396] gain_of_function of ERBB2 H878Y,(ERBB2 H878R) heterodimers [plasma membrane] [EntityFunctionalStatus:9655397] gain_of_function of ERBB2 T862A heterodimers [plasma membrane] List all 43 refering instances
(output)	[Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens]
(physicalEntity)	[CatalystActivity:1963566] protein tyrosine kinase activity of ERBB2 heterodimers [plasma membrane]
(updatedInstance)	[_UpdateTracker:9871706] Update Tracker - [DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] - v41:[updateContainedMemberOrCandidate] [_UpdateTracker:9873001] Update Tracker - [DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] - v42:[updateContainedMemberOrCandidate] [_UpdateTracker:9888338] Update Tracker - [DefinedSet:1963573] ERBB2 heterodimers [plasma membrane] - v46:[removeCompartment]
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No pathways have been reviewed or authored by ERBB2 heterodimers [plasma membrane] (1963573)