Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person ERBB2, which does not bind any known ligand, is activated th...
| Class:Id | Summation:1963564 |
|---|---|
| _displayName | ERBB2, which does not bind any known ligand, is activated th... |
| _timestamp | 2019-07-26 14:16:13 |
| created | [InstanceEdit:1963565] Orlic-Milacic, M, 2011-11-03 |
| modified | [InstanceEdit:9655818] Orlic-Milacic, Marija, 2019-07-26 |
| text | ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member. ERBB2 heterodimerization partners are EGF-stimulated EGFR (Wada et al. 1990, Karunagaran et al. 1996), ERBB3 stimulated by neuregulins NRG1 or NRG2 (Pinkas-Kramarski et al. 1996), and ERBB4 stimulated by neuregulins or EGF-like ligands (Li et al. 2007). In the process of dimerization, ERBB2 dissociates from chaperone proteins HSP90 and CDC37 (Xu et al 2001, Citri et al. 2004). Activated ERBB2 also dissociates from ERBB2IP, the protein responsible for proper localization of ERBB2 to basolateral membranes of epithelial cells (Borg et al. 2000). |
| (summation) | [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by ERBB2, which does not bind any known ligand, is activated th... (1963564)
