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Details on Person APC is phosphorylated on the 20 aa repeats by CK1 and potent...

Class:IdSummation:196308
_displayNameAPC is phosphorylated on the 20 aa repeats by CK1 and potent...
_timestamp2011-07-22 21:01:38
created[InstanceEdit:196307] Matthews, L, 2007-04-19 13:47:08
literatureReference[LiteratureReference:195314] beta-catenin destruction complex: insights and questions from a structural perspective
[LiteratureReference:196288] Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein
[LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
[LiteratureReference:196248] The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
[LiteratureReference:196293] Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
modified[InstanceEdit:197173] Matthews, L, 2007-05-01 10:25:12
[InstanceEdit:1458945] Rothfels, K, 2011-07-22
textAPC is phosphorylated on the 20 aa repeats by CK1 and potentially GSK-3. This significantly increases the binding affinity of the APC 20 aa repeats for beta-catenin, causing one of them to bind b-catenin in the same region as beta-catenin binds Axin, thus displacing beta-catenin from Axin ( Step 5 above) (Reviewed in Kimelman, 2006).
(summation)[Reaction:195275] Phosphorylation of APC component of the destruction complex [Homo sapiens]
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