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Details on Person STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space

Class:Id	Reaction:196126
_displayName	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space
_doRelease	TRUE
_timestamp	2025-08-13 19:23:56
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:9954142] molecular carrier activity of STAR [mitochondrial intermembrane space]
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:196115] D'Eustachio, P, 2007-04-17 18:04:28
crossReference	[DatabaseIdentifier:9954143] RHEA:39747
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[Complex:196124] STARD3:STARD3NL, STARD4,6:CHOL [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06
literatureReference	[LiteratureReference:8873807] The binding site specificity of STARD4 subfamily: Breaking the cholesterol paradigm
modified	[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:555080] D'Eustachio, P, 2010-03-22 [InstanceEdit:8873825] Jassal, Bijay, 2016-05-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9954144] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9954148] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
name	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space cholesterol(in) = cholesterol(out)
output	[CandidateSet:196094] STARD3:STARD3NL, STARD4,6 [cytosol] [Homo sapiens] [SimpleEntity:193156] CHOL [mitochondrial inner membrane]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21 [InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360894] R-HSA-196126.4
structureModified	[InstanceEdit:9954144] D'Eustachio, Peter, 2025-06-06
summation	[Summation:193130] CHOL (cholesterol) traverses the cytosol and the mitochondri...
(hasEvent)	[Pathway:196108] Pregnenolone biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:193054] Oxidation of cholesterol to 22beta-hydroxycholesterol [Homo sapiens]
(replacementInstances)	[_Deleted:9954145] Deletion of instance: 196086
(updatedInstance)	[_UpdateTracker:9782873] Update Tracker - [Reaction:196126] CHOL translocates from cytosol to mitochondrial intermembrane space - v58:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9964713] Update Tracker - [Reaction:196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space - v94:[addInput, add_removeOutput, modifyText, removeCatalystActivity]
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