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Details on Person Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol

Class:Id	Reaction:195664
_displayName	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
_doRelease	TRUE
_timestamp	2025-04-11 19:40:12
authored	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
catalystActivity	[CatalystActivity:195666] C-5 sterol desaturase activity of SC5D [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643764] C-5 sterol desaturase activity of SC5D [endoplasmic reticulum membrane] Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:195668] D'Eustachio, P, 2007-04-12 15:55:15
crossReference	[DatabaseIdentifier:9945227] RHEA:34004
edited	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
input	[SimpleEntity:195691] CHdOL [endoplasmic reticulum membrane] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:195693] Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase [LiteratureReference:195667] Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency
modified	[InstanceEdit:195713] D'Eustachio, P, 2007-04-13 17:54:25 [InstanceEdit:196422] D'Eustachio, P, 2007-04-21 18:35:08 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945226] D'Eustachio, Peter, 2025-04-11
name	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + O2 + H(+) => 7-dehydrodesmosterol + NADP(+) + 2 H2O
output	[SimpleEntity:195655] 7dhDESOL [endoplasmic reticulum membrane] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:195690] Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol [Homo sapiens] [Reaction:194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:196409] Jassal, B, 2007-04-21 18:33:24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360609] R-HSA-195664.4
summation	[Summation:195695] Cholesta-7,24-dien-3beta-ol, NADPH + H+, and O2 react to for...
(hasEvent)	[Pathway:6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) [Homo sapiens]
(precedingEvent)	[Reaction:196402] Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol [Homo sapiens]
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